Purple pitanga extract (Eugenia uniflora) attenuates oxidative stress induced by MPTP.
Rats
Male
Animals
Mice
Antioxidants
/ pharmacology
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
/ pharmacology
Eugenia
/ metabolism
Rats, Wistar
Oxidative Stress
Neuroprotective Agents
/ pharmacology
Substantia Nigra
/ metabolism
Plant Extracts
/ pharmacology
Mice, Inbred C57BL
Disease Models, Animal
Antioxidant
Brazilian cherry
Neuroprotection
Parkinson’s Disease
Journal
Metabolic brain disease
ISSN: 1573-7365
Titre abrégé: Metab Brain Dis
Pays: United States
ID NLM: 8610370
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
received:
26
05
2023
accepted:
25
10
2023
medline:
22
11
2023
pubmed:
3
11
2023
entrez:
3
11
2023
Statut:
ppublish
Résumé
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been widely used due to its specific and reproducible neurotoxic effect on the nigrostriatal system, being considered a convenient model of dopaminergic neurodegeneration to study interventions therapeutics. The purple pitanga (Eugenia uniflora) is a polyphenol-rich fruit with antioxidant and antidepressant properties, among others. Therefore, this study investigated the effect of purple pitanga extract (PPE) on acute early oxidative stress induced by intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in rats. Male Wistar rats were pre-treated orally with PPE (1000 mg/kg) or vehicle. After 24 h, MPTP (0.1 mg/10µL/nostril) or vehicle was administered bilaterally into the animal's nostrils, and 6 h later, the olfactory bulb (OB), striatum (ST), and substantia nigra (SN) were collected to evaluate the oxidative stress parameters. Our findings revealed that OB and SN were the most affected areas after 6 h of MPTP infusion; an early increase in reactive oxygen species (ROS) levels was observed, while pretreatment with a single dose of PPE prevented this increment. No differences in thiobarbituric acid reactive species (TBARS) and 3-nitrotyrosine (3-NT) formation were observed, although 4-hydroxy-2-nonenal (4-HNE) levels increased, which is the most toxic form of lipid peroxidation, in the MPTP group. The PPE pretreatment could prevent this increase by increasing the NPSH levels previously decreased by MPTP. Furthermore, PPE prevents the Na+/K + ATPase strongly inhibited by MPTP, showing the neuroprotective capacity of the PPE by inhibiting the MPTP-generated oxidation. Thus, we demonstrated for the first time the antioxidant and neuroprotective effects of PPE against the early MPTP neurotoxicity.
Identifiants
pubmed: 37921949
doi: 10.1007/s11011-023-01318-z
pii: 10.1007/s11011-023-01318-z
doi:
Substances chimiques
Antioxidants
0
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
9P21XSP91P
Neuroprotective Agents
0
Plant Extracts
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2615-2625Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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