Work Difficulties in People with Multiple Sclerosis.
Disability
Employment
Multiple sclerosis
Work difficulties
Journal
Journal of occupational rehabilitation
ISSN: 1573-3688
Titre abrégé: J Occup Rehabil
Pays: Netherlands
ID NLM: 9202814
Informations de publication
Date de publication:
03 Nov 2023
03 Nov 2023
Historique:
accepted:
17
10
2023
medline:
3
11
2023
pubmed:
3
11
2023
entrez:
3
11
2023
Statut:
aheadofprint
Résumé
This study identifies potential predictors of unemployment and describes specific work difficulties and their determinants in a subgroup of employed people with multiple sclerosis (PwMS). The specific work difficulties were evaluated using a validated tool that measures the impact of respondents' symptoms and of workplace features. A cross-sectional study was carried out in Italy during 2021-2022. The subjects included were adults (18-65 years) with a diagnosis of MS, currently employed or unemployed. Logistic regression models were used to determine the association between each potential determinant and employment status, while linear regression models were used to determine the association between determinants and specific work difficulties. The main risk factors associated with a higher risk of being unemployed were being older, living in the South of Italy/islands, and having a higher disability level, while protective factors against unemployment were having a high level of education and 'stable' employment (an open-ended contract). Fatigue was found to be associated with all work difficulties analyzed; mood disorders emerged as the main predictors of mental health-related work difficulties; level of disability and comorbidity significantly impacted physical health-related ones, and a good quality of life was found to improve both workplace-related and mental health-related difficulties at work. Identifying the most significant difficulties is a crucial step in the development of vocational rehabilitation interventions tailored to maximize the ability of PwMS to handle their job-related duties and demands.
Identifiants
pubmed: 37921967
doi: 10.1007/s10926-023-10149-9
pii: 10.1007/s10926-023-10149-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Italian Workers' Compensation Authority (INAIL)
ID : Bando BRIC 2019_ID 24
Informations de copyright
© 2023. The Author(s).
Références
Walton C, King R, Rechtman L, Kaye W, Leray E, Marrie RA, Robertson N, La Rocca N, Uitdehaag B, van der Mei I, Wallin M, Helme A, Angood Napier C, Rijke N, Baneke P. Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition. Mult Scler. 2020;26(14):1816–1821. https://doi.org/10.1177/1352458520970841 .
doi: 10.1177/1352458520970841
pubmed: 33174475
pmcid: 7720355
Confavreux C, Vukusic S. Age at disability milestones in multiple sclerosis. Brain. 2006;129(Pt 3):595–605. https://doi.org/10.1093/brain/awh714 .
doi: 10.1093/brain/awh714
pubmed: 16415309
Thompson AJ, Baranzini SE, Geurts J, Hemmer B, Ciccarelli O. Multiple sclerosis. Lancet. 2018;391(10130):1622–1636.
doi: 10.1016/S0140-6736(18)30481-1
pubmed: 29576504
Johnson KL, Yorkston KM, Klasner ER, Kuehn CM, Johnson E, Amtmann D. The cost and benefits of employment: a qualitative study of experience of persons with multiple sclerosis. Arch Phys Med Rehabil. 2004;85:201–209.
doi: 10.1016/S0003-9993(03)00614-2
pubmed: 14966703
Kobelt G, Thompson A, Berg J, Gannedahl M, Eriksson J, MSCOI Study Group; European Multiple Sclerosis Platform. New insights into the burden and costs of multiple sclerosis in Europe. Mult Scler. 2017;23(8):1123–1136.
doi: 10.1177/1352458517694432
pubmed: 28273775
pmcid: 5476197
Bøe Lunde HM, Telstad W, Grytten N, Kyte L, Aarseth J, Myhr KM, Bø L. Employment among patients with multiple sclerosis-a population study. PLoS One. 2014;9(7):e103317. https://doi.org/10.1371/journal.pone.0103317 .
doi: 10.1371/journal.pone.0103317
pubmed: 25054972
pmcid: 4108421
Moore P, Harding KE, Clarkson H, Pickersgill TP, Wardle M, Robertson NP. Demographic and clinical factors associated with changes in employment in multiple sclerosis. Mult Scler. 2013;19(12):1647–1654. https://doi.org/10.1177/1352458513481396 .
doi: 10.1177/1352458513481396
pubmed: 23652213
Vitturi BK, Rahmani A, Dini G, Montecucco A, Debarbieri N, Sbragia E, Bandiera P, Ponzio M, Battaglia MA, Manacorda T, Persechino B, Buresti G, Inglese M, Durando P. Spatial and temporal distribution of the prevalence of unemployment and early retirement in people with multiple sclerosis: a systematic review with meta-analysis. BMJ Open. 2022;12:e058948. https://doi.org/10.1136/bmjopen-2021-058948 .
doi: 10.1136/bmjopen-2021-058948
pubmed: 35777874
pmcid: 9252209
Sobocki P, Pugliatti M, Lauer K, Kobelt G. Estimation of the cost of MS in Europe: extrapolations from a multinational cost study. Mult Scler. 2007;13(8):1054–1064.
doi: 10.1177/1352458507077941
pubmed: 17623729
Ponzio M, Gerzeli S, Brichetto G, Bezzini D, Mancardi GL, Zaratin P, Battaglia MA. Economic impact of multiple sclerosis in Italy: focus on rehabilitation costs. Neurol Sci. 2014;36(2):227–234.
doi: 10.1007/s10072-014-1925-z
pubmed: 25109816
Bergamaschi R, Quaglini S, Tavazzi E, Amato MP, Paolicelli D, Zipoli V, Romani A, Tortorella C, Portaccio E, D’Onghia M, Garberi F, Bargiggia V, Trojano M. Immunomodulatory therapies delay Disease progression in multiple sclerosis. Mult Scler. 2016;22(13):1732–1740. https://doi.org/10.1177/1352458512445941 .
doi: 10.1177/1352458512445941
pubmed: 22653657
Schiavolin S, Leonardi M, Giovannetti AM, Antozzi C, Brambilla L, Confalonieri P, Mantegazza R, Raggi A. Factors related to difficulties with employment in patients with multiple sclerosis: a review of 2002–2011 literature. Int J Rehabil Res. 2013;36(2):105–111. https://doi.org/10.1097/MRR.0b013e32835c79ea .
doi: 10.1097/MRR.0b013e32835c79ea
pubmed: 23238667
Clemens L, Langdon D. How does cognition relate to employment in multiple sclerosis? A systematic review. Mult Scler Relat Disord. 2018;26:183–191. https://doi.org/10.1016/j.msard.2018.09.018 .
doi: 10.1016/j.msard.2018.09.018
pubmed: 30268039
Gerhard L, Dorstyn DS, Murphy G, Roberts RM. Neurological, physical and sociodemographic correlates of employment in multiple sclerosis: a meta-analysis. J Health Psychol. 2020;25(1):92–104. https://doi.org/10.1177/1359105318755262 .
doi: 10.1177/1359105318755262
pubmed: 29460636
Ponzio M, Brichetto G, Zaratin P, Battaglia MA. Workers with disability: the case of multiple sclerosis. Neurol Sci. 2015;36:1835–1841. https://doi.org/10.1007/s10072-015-2265-3 .
doi: 10.1007/s10072-015-2265-3
pubmed: 26017351
Miller A, Dishon S. Health-related quality of life in multiple sclerosis: the impact of disability, gender and employment status. Qual Life Res. 2006;15:259–271.
doi: 10.1007/s11136-005-0891-6
pubmed: 16468081
Bishop M, Frain MP, Rumrill PD, Rymond C. The relationship of self-management and disease modifying therapy use to employment status among adults with multiple sclerosis. J Vocat Rehabil. 2009;31(2):119–127.
doi: 10.3233/JVR-2009-480
Vitturi BK, Rahmani A, Dini G, Montecucco A, Debarbieri N, Bandiera P, Ponzio M, Battaglia MA, Brichetto G, Inglese M, Persechino B, Durando P. Work barriers and job adjustments of people with multiple sclerosis: a systematic review. J Occup Rehabil 2022 Nov. 2022. https://doi.org/10.1007/s10926-022-10084-1 .
doi: 10.1007/s10926-022-10084-1
Ford HL, Wicks CR, Stroud A, Tennant A. Psychological determinants of job retention in multiple sclerosis. Mult Scler. 2019;25(3):419–426. https://doi.org/10.1177/1352458518754362 .
doi: 10.1177/1352458518754362
pubmed: 29363395
Vitturi BK, Rahmani A, Dini G, Montecucco A, Debarbieri N, Sbragia E, Bandiera P, Ponzio M, Battaglia MA, Manacorda T, Persechino B, Buresti G, Inglese M, Durando P. Occupational outcomes of people with multiple sclerosis: a scoping review. BMJ Open. 2022;12(7):e058948. https://doi.org/10.1136/bmjopen-2021-058948 .
doi: 10.1136/bmjopen-2021-058948
pubmed: 35777874
pmcid: 9252209
Dorstyn DS, Roberts RM, Murphy G, Haub R. Employment and multiple sclerosis: a meta-analytic review of psychological correlates. J Health Psychol. 2019;24:38–51.
doi: 10.1177/1359105317691587
pubmed: 28810436
BSRM. Vocational Rehabilitation-The Way Forward. 2nd edition. BSRM Working Party Report. 2003.
De Dios Pérez B, Radford K, das Nair R. Experiences of people with multiple sclerosis at work: Towards the understanding of the needs for a job retention vocational rehabilitation intervention. Work. 2022;72(1):303–313. https://doi.org/10.3233/WOR-210012 .
doi: 10.3233/WOR-210012
pubmed: 35431210
Chiu C-Y, Chan F, Bishop M, da Silva Cardoso E, O’Neill J. State vocational rehabilitation services and employment in multiple sclerosis. Mult Scler J. 2013;19:1655–1664.
doi: 10.1177/1352458513482372
Marrie RA, Miller A, Sormani MP, Thompson A, Waubant E, Trojano M, O’Connor P, Fiest K, Reider N, Reingold S, Cohen JA. Attendees of the International Workshop on Comorbidity in Multiple Sclerosis. Recommendations for observational studies of comorbidity in multiple sclerosis. Neurology. 2016;86(15):1446–1453.
doi: 10.1212/WNL.0000000000002474
pubmed: 26865523
pmcid: 4831039
Raggi A, Giovannetti AM, Schiavolin S, Confalonieri P, Brambilla L, Brenna G, Cortese F, Covelli V, Frangiamore R, Moscatelli M, Ponzio M, Torri Clerici V, Zaratin P, Mantegazza R, Leonardi M. Development and validation of the multiple sclerosis questionnaire for the evaluation of job difficulties (MSQ-Job). Acta Neurol Scand. 2015;132:226–234.
doi: 10.1111/ane.12387
pubmed: 25690402
Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an Expanded Disability Status Scale (EDSS). Neurology. 1983;33:1444–1452.
doi: 10.1212/WNL.33.11.1444
pubmed: 6685237
Hohol MJ, Orav EJ, Weiner HL. Disease steps in multiple sclerosis: a simple approach to evaluate disease progression. Neurology. 1995;45:251–255.
doi: 10.1212/WNL.45.2.251
pubmed: 7854521
Tacchino A, Brichetto G, Zaratin P, Battaglia MA, Ponzio M. Self-assessment reliability in multiple sclerosis: the role of socio-demographic, clinical, and quality of life aspects. Neurol Sci. 2019;40(3):617–620. https://doi.org/10.1007/s10072-018-3589-6 .
doi: 10.1007/s10072-018-3589-6
pubmed: 30291467
Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67:361–370.
doi: 10.1111/j.1600-0447.1983.tb09716.x
pubmed: 6880820
Honarmand K, Feinstein A. Validation of the hospital anxiety and depression scale for use with multiple sclerosis patients. Mult Scler. 2009;15:1518–1524.
doi: 10.1177/1352458509347150
pubmed: 19965520
Costantini M, Musso M, Viterbori P, Bonci F, Del Mastro L, Garrone O, Venturini M, Morasso G. Detecting psychological distress in cancer patients: validity of the Italian version of the hospital anxiety and depression scale. Support Care Cancer. 1999;7:121–127.
doi: 10.1007/s005200050241
pubmed: 10335929
Zimet GD, Dahlem NW, Zimet SG, Farley GK. The Multidimensional Scale of Perceived Social Support. J Personality Assess. 1988;52:30–41. https://doi.org/10.1080/00223891.1990.9674095el .
doi: 10.1080/00223891.1990.9674095el
Aleni Sestito L, Cozzolino MD, Menna P, Ragozini GE. Sica LS Contribution to the validation of Italian version of the Social Support Scale by Susan Harter. Bollettino Psicologia Applicata. 2008;254:33–43.
Baylor C, Yorkston K, Bamer A, Britton D, Amtmann D. Variables associated with communicative participation in people with multiple sclerosis: A regression analysis. Am J Speech Lang Pathol 2010 May. 2010;19(2):143–153. https://doi.org/10.1044/1058-0360(2009/08-0087 .
doi: 10.1044/1058-0360(2009/08-0087
EuroQol G. EuroQol–a new facility for the measurement of health-related quality of life. Health Policy. 1990;16(3):199–208.
doi: 10.1016/0168-8510(90)90421-9
Scalone L, Cortesi PA, Ciampichini R, et al. Italian population-based values of EQ-5D health states. Value Health. 2013;16:814–822.
doi: 10.1016/j.jval.2013.04.008
pubmed: 23947975
Annual report 2022- The state of the Nation, Italian National Institute of Statistics (ISTAT). https://www.istat.it/it/files//2022/09/Annual-Report-2022_Summary.pdf Accessed 25 July 2023.
Guerra T, Pipoli A, Viterbo RG, Manghisi N, Paolicelli D, Iaffaldano P, Di Lorenzo. L predictors of unemployment status in people with relapsing multiple sclerosis: a single center experience. Neurol Sci. 2022;43(7):4387–4392. https://doi.org/10.1007/s10072-022-06029-4 .
doi: 10.1007/s10072-022-06029-4
pubmed: 35322339
pmcid: 9213301
Ross CE, Wu CL. The links between Education and Health. Am Sociol Rev. 1995;60:719–745.
doi: 10.2307/2096319
2021. FEPS, Fina S, Heider B, Prota F. Unequal Italy Regional socio-economic disparities in Italy. Foundation for European Progressive Study. https://feps-europe.eu/wp-content/uploads/2021/07/Unequal-Italy-Regional-socio-economic-disparities-in-Italy.pdf . Accessed 25 July 2023.
Simmons RD, Tribe KL, McDonald EA. Living with multiple sclerosis: longitudinal changes in employment and the importance of symptom management. J Neurol. 2010;257:926–936. https://doi.org/10.1007/s00415-009-5441-7 .
doi: 10.1007/s00415-009-5441-7
pubmed: 20084515
Pérez de Heredia-Torres M, Huertas-Hoyas E, Sánchez-Camarero C, Máximo-Bocanegra N, Alegre-Ayala J, Sánchez-Herrera-Baeza P, Martínez-Piédrola RM, García-Bravo C, Mayoral-Martín A, Serrada-Tejeda S. Occupational performance in multiple sclerosis and its relationship with quality of life and fatigue. Eur J Phys Rehabil Med. 2020;56(2):148–154. https://doi.org/10.23736/S1973-9087.20.05914-6 .
doi: 10.23736/S1973-9087.20.05914-6
pubmed: 31976636
Tinghög P, Björkenstam C, Carstensen J, Jansson C, Glaser A, Hillert J, Alexanderson K. Co-morbidities increase the risk of disability pension among MS patients: a population-based nationwide cohort study. BMC Neurol. 2014;14:117. https://doi.org/10.1186/1471-2377-14-117 .
doi: 10.1186/1471-2377-14-117
pubmed: 24894415
pmcid: 4055212
Raggi A, Covelli V, Schiavolin S, Scaratti C, Leonardi M, Willems M. Work-related problems in multiple sclerosis: a literature review on its associates and determinants. Disabil Rehabil. 2016;38(10):936–944.
doi: 10.3109/09638288.2015.1070295
pubmed: 26213244
Rumrill P, Li J, Strauser D, Roessler RT, Bishop M, Chan F, Adams C, Leslie M. Personal, health and function, and career maintenance factors as determinants of quality of life among employed people with multiple sclerosis. Work. 2020;67(1):81–94. https://doi.org/10.3233/WOR-203254 .
doi: 10.3233/WOR-203254
pubmed: 32986637
Ivandic I, Kamenov K, Rojas D, Cerón G, Nowak D, Sabariego C. Determinants of work performance in workers with depression and anxiety: a cross-sectional study. Int J Environ Res Public Health. 2017;14(5):466. https://doi.org/10.3390/ijerph14050466 .
doi: 10.3390/ijerph14050466
pubmed: 28445433
pmcid: 5451917
Kim TJ, von dem Knesebeck O. Perceived job insecurity, unemployment and depressive symptoms: a systematic review and meta-analysis of prospective observational studies. Int Arch Occup Environ Health. 2016;89:561–573. https://doi.org/10.1007/s00420-015-1107-1 .
doi: 10.1007/s00420-015-1107-1
pubmed: 26715495
Ribbons K, Lea R, Schofield PW, Lechner-Scott J. Anxiety levels are independently associated with cognitive performance in an australian multiple sclerosis patient cohort. J Neuropsychiatry Clin Neurosci. 2017;29:128–134. https://doi.org/10.1176/appi.neuropsych.16050085 .
doi: 10.1176/appi.neuropsych.16050085
pubmed: 27899051
van der Hiele K, van Gorp DAM, Heerings MAP, et al. The MS@Work study: a 3-year prospective observational study on factors involved with work participation in patients with relapsing-remitting multiple sclerosis. BMC Neurol. 2015;15:134.
doi: 10.1186/s12883-015-0375-4
pubmed: 26264389
pmcid: 4531500
Podda J, Ponzio M, Messmer Uccelli M, Pedullà L, Bozzoli F, Molinari F, Monti Bragadin M, Battaglia MA, Zaratin P, Brichetto G, Tacchino A. Predictors of clinically significant anxiety in people with multiple sclerosis: a one-year follow-up study. Mult Scler Relat Disord. 2020;45:102417.
doi: 10.1016/j.msard.2020.102417
pubmed: 32736214
van Egmond E, van der Hiele K, van Gorp D, Jongen PJ, van der Klink J, Reneman MF, Beenakker E, van Eijk J, Frequin S, de Gans K, van Geel BM, Gerlach O, Hengstman G, Mostert JP, Verhagen W, Middelkoop H, Visser LH. Work difficulties in people with multiple sclerosis: the role of anxiety, depression and coping. Mult Scler J Exp Transl Clin. 2022;8(3):20552173221116280. https://doi.org/10.1177/20552173221116282 .
doi: 10.1177/20552173221116282
pubmed: 36081414
pmcid: 9445483
Fisk JD, Pontefract A, Ritvo PG, Archibald CJ, Murray T. The impact of fatigue on patients with multiple sclerosis. Can J Neurol Sci /J Can des Sci Neurol. 1994;21:9–14.
doi: 10.1017/S0317167100048691
van Wegen J, van Egmond EEA, Benedict RHB, Beenakker EAC, van Eijk JJJ, Frequin STFM, de Gans K, Gerlach OHH, van Gorp DAM, Hengstman GJD, Jongen PJ, van der Klink JJL, Reneman MF, Verhagen WIM, Middelkoop HAM, Visser LH, Hulst HE, van der Hiele K. Subjective cognitive impairment is related to work status in people with multiple sclerosis. IBRO Neurosci Rep. 2022;13:513–522.
doi: 10.1016/j.ibneur.2022.10.016
pubmed: 36457855
pmcid: 9706155
Janardhan V, Bakshi R. Quality of life in patients with multiple sclerosis: the impact of fatigue and depression. J Neurol Sci. 2002;205:51–58.
doi: 10.1016/S0022-510X(02)00312-X
pubmed: 12409184
Scoppetta A, Davern E, Geyer L. (2019): Job carving and Job crafting. Joint paper of the ETN and LTU project (on behalf of AEIDL/European Commission). Brussels: ESF Transnational Platform. https://www.euro.centre.org/publications/detail/3479 . Accessed 15 May 2023.
Good A, Stokes S, Jerrams-Smith J. Elderly, novice users and health information websites: issues of accessibility and usability. J Healthc Inf Manag. 2007;21(3):72–79.
pubmed: 19195297
Hayter AL, Salkovskis PM, Silber E, Morris RG. The impact of health anxiety in patients with relapsing remitting multiple sclerosis: misperception, misattribution and quality of life. Br J Clin Psychol. 2016;55:371–386.
doi: 10.1111/bjc.12106
pubmed: 26806805