Electroconductive Collagen-Carbon Nanodots Nanocomposite Elicits Neurite Outgrowth, Supports Neurogenic Differentiation and Accelerates Electrophysiological Maturation of Neural Progenitor Spheroids.
carbon nanodots
electroconductive hydrogels
iPSC-derived spheroids
multielectrode arrays
neuronal differentiation
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
03 Nov 2023
03 Nov 2023
Historique:
revised:
04
10
2023
received:
14
06
2023
pubmed:
6
11
2023
medline:
6
11
2023
entrez:
3
11
2023
Statut:
aheadofprint
Résumé
Neuronal disorders are characterized by the loss of functional neurons and disrupted neuroanatomical connectivity, severely impacting the quality of life of patients. This study investigates a novel electroconductive nanocomposite consisting of glycine-derived carbon nanodots (GlyCNDs) incorporated into a collagen matrix and validates its beneficial physicochemical and electro-active cueing to relevant cells. To this end, this work employs mouse induced pluripotent stem cell (iPSC)-derived neural progenitor (NP) spheroids. The findings reveal that the nanocomposite markedly augmented neuronal differentiation in NP spheroids and stimulate neuritogenesis. In addition, this work demonstrates that the biomaterial-driven enhancements of the cellular response ultimately contribute to the development of highly integrated and functional neural networks. Lastly, acute dizocilpine (MK-801) treatment provides new evidence for a direct interaction between collagen-bound GlyCNDs and postsynaptic N-methyl-D-aspartate (NMDA) receptors, thereby suggesting a potential mechanism underlying the observed cellular events. In summary, the findings establish a foundation for the development of a new nanocomposite resulting from the integration of carbon nanomaterials within a clinically approved hydrogel, toward an effective biomaterial-based strategy for addressing neuronal disorders by restoring damaged/lost neurons and supporting the reestablishment of neuroanatomical connectivity.
Identifiants
pubmed: 37922888
doi: 10.1002/adhm.202301894
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2301894Subventions
Organisme : Government of Canada's New Frontiers in Research Fund
ID : NFRFE-2019-00039
Organisme : Canada Foundation for Innovation (CFI)
Organisme : Ontario Ministry of Research and Innovation
Organisme : Natural Sciences and Engineering Research Council of Canada (NSERC)
Organisme : Concordia University Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Informations de copyright
© 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.
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