[Translated article] Sarcoid-like Reactions to Immune Checkpoint Inhibitors.
Granulomas
Immune checkpoint inhibitors
Immunotherapy
Inhibidores de puntos de control inmunitario
Inmunoterapia
Sarcoidosis
Journal
Actas dermo-sifiliograficas
ISSN: 1578-2190
Titre abrégé: Actas Dermosifiliogr
Pays: Spain
ID NLM: 0373062
Informations de publication
Date de publication:
03 Nov 2023
03 Nov 2023
Historique:
received:
14
11
2022
accepted:
01
03
2023
pubmed:
6
11
2023
medline:
6
11
2023
entrez:
3
11
2023
Statut:
aheadofprint
Résumé
Immune checkpoint inhibitors (ICIs) can cause immune-mediated cutaneous adverse events, including sarcoid-like reactions. The aim of this study was to retrospectively analyze clinical and histologic data from patients who developed cutaneous sarcoid-like reactions between 2019 and 2022 while under treatment with ICIs. We studied 7 patients (6 women and 1 man) with a median age of 65years. Median time to onset of symptoms was 4months. The most common presentation was papular sarcoidosis of the knees followed by subcutaneous sarcoidosis. Diagnosis was confirmed histologically in all cases, and no differences were observed relative to idiopathic sarcoidosis. Discontinuation of ICI therapy was required in just two patients. ICI-induced sarcoid-like reactions tend to be mild and generally do not require treatment discontinuation. Histologic confirmation is essential for distinguishing these reactions from tumor progression.
Identifiants
pubmed: 37923080
pii: S0001-7310(23)00864-5
doi: 10.1016/j.ad.2023.03.011
pii:
doi:
Types de publication
Case Reports
Langues
eng
spa
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.