Rapid threat assessment in the Drosophila thermosensory system.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
03 11 2023
03 11 2023
Historique:
received:
19
04
2023
accepted:
23
10
2023
medline:
6
11
2023
pubmed:
4
11
2023
entrez:
4
11
2023
Statut:
epublish
Résumé
Neurons that participate in sensory processing often display "ON" responses, i.e., fire transiently at the onset of a stimulus. ON transients are widespread, perhaps universal to sensory coding, yet their function is not always well-understood. Here, we show that ON responses in the Drosophila thermosensory system extrapolate the trajectory of temperature change, priming escape behavior if unsafe thermal conditions are imminent. First, we show that second-order thermosensory projection neurons (TPN-IIIs) and their Lateral Horn targets (TLHONs), display ON responses to thermal stimuli, independent of direction of change (heating or cooling) and of absolute temperature. Instead, they track the rate of temperature change, with TLHONs firing exclusively to rapid changes (>0.2 °C/s). Next, we use connectomics to track TLHONs' output to descending neurons that control walking and escape, and modeling and genetic silencing to demonstrate how ON transients can flexibly amplify aversive responses to small thermal change. Our results suggest that, across sensory systems, ON transients may represent a general mechanism to systematically anticipate and respond to salient or dangerous conditions.
Identifiants
pubmed: 37923719
doi: 10.1038/s41467-023-42864-5
pii: 10.1038/s41467-023-42864-5
pmc: PMC10624821
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7067Subventions
Organisme : NINDS NIH HHS
ID : R01 NS086859
Pays : United States
Organisme : NEI NIH HHS
ID : R21 EY031849
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS130554
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007909
Pays : United States
Informations de copyright
© 2023. The Author(s).
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