Cancer mortality after kidney transplantation: A multicenter cohort study in Italy.
cancer mortality
cohort study
immunosuppression
kidney transplant
virus-related malignancy
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
04 Nov 2023
04 Nov 2023
Historique:
revised:
05
10
2023
received:
28
07
2023
accepted:
16
10
2023
medline:
4
11
2023
pubmed:
4
11
2023
entrez:
4
11
2023
Statut:
aheadofprint
Résumé
Kidney transplant (KT) recipients are known to be at risk of developing several cancer types; however, cancer mortality in this population is underinvestigated. Our study aimed to assess the risk of cancer death among Italian KT recipients compared to the corresponding general population. A cohort study was conducted among 7373 individuals who underwent KT between 2003 and 2020 in 17 Italian centers. Date and cause of death were retrieved until 31 December 2020. Indirect standardization was used to estimate standardized mortality ratios (SMRs) and corresponding 95% confidence intervals (CIs). Cancer was the most common cause of death among the 7373 KT recipients, constituting 32.4% of all deaths. A 1.8-fold excess mortality (95% CI: 1.59-2.09) was observed for all cancers combined. Lymphomas (SMR = 6.17, 95% CI: 3.81-9.25), kidney cancer (SMR = 5.44, 95% CI: 2.97-8.88) and skin melanoma (SMR = 3.19, 95% CI: 1.03-6.98) showed the highest excess death risks. In addition, SMRs were increased about 1.6 to 3.0 times for cancers of lung, breast, bladder and other hematopoietic and lymphoid tissues. As compared to the general population, relative cancer mortality risk remained significantly elevated in all age groups though it decreased with increasing age. A linear temporal increase in SMR over time was documented for all cancers combined (P < .01). Our study documented significantly higher risks of cancer death in KT recipients than in the corresponding general population. Such results support further investigation into the prevention and early detection of cancer in KT recipients.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CRO Aviano "5x1000 (Redditi 2018)"
Organisme : Italian Association for Research on Cancer
ID : 19112
Organisme : Italian Ministry of Health
Investigateurs
Lucia Fratino
(L)
Federica Toffolutti
(F)
Alessandro Agresta
(A)
Enrico Girardi
(E)
Alessandra Nappo
(A)
Elisa Boccalon
(E)
Caterina Di Bella
(C)
Erica Nuzzolese
(E)
Paolo Rigotti
(P)
Antonio Lavacca
(A)
Valeriana Colombo
(V)
Marialuisa Querques
(M)
Stefano Possenti
(S)
Silvio Sandrini
(S)
Laura Panicali
(L)
Chiara Valentini
(C)
Elena Cremaschi
(E)
Umberto Maggiore
(U)
Alessandra Palmisano
(A)
Carlo Pellegrino
(C)
Carmelo Puliatti
(C)
Giuseppe Grandaliano
(G)
Maria Paola Salerno
(MP)
Elisabetta Schifano
(E)
Patrizia Silvestri
(P)
Gionata Spagnoletti
(G)
Carlo Maria Alfieri
(CM)
Giuseppe Castellano
(G)
Evaldo Favi
(E)
Mariano Ferraresso
(M)
Samuele Iesari
(S)
Daniela Corona
(D)
Costanza Distefano
(C)
Pierfrancesco Veroux
(P)
Francesca Blasi
(F)
Francesca Romano
(F)
Luca Toti
(L)
Cristina Cornella
(C)
Guido Merlotti
(G)
Marco Quaglia
(M)
Maria Cristina Maresca
(MC)
Loreto Gesualdo
(L)
Elisabetta Carta
(E)
Gian Benedetto Piredda
(GB)
Marco De Cicco
(M)
Giuseppe Ietto
(G)
Domenico Iovino
(D)
Francesco Perna
(F)
Laura Lancione
(L)
Alessandra Panarese
(A)
Antonio Amato
(A)
Barbara Buscemi
(B)
Informations de copyright
© 2023 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.
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