Mitochondrial dysfunction: a new molecular mechanism of intervertebral disc degeneration.
Autophagy
Intervertebral disc degeneration
Mitochondrial dysfunction
Nucleus pulposus cells
Oxidative stress
Journal
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
ISSN: 1420-908X
Titre abrégé: Inflamm Res
Pays: Switzerland
ID NLM: 9508160
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
05
09
2023
accepted:
25
10
2023
revised:
22
10
2023
medline:
20
11
2023
pubmed:
5
11
2023
entrez:
5
11
2023
Statut:
ppublish
Résumé
Intervertebral disc degeneration (IVDD) is a chronic degenerative orthopedic illness that causes lower back pain as a typical clinical symptom, severely reducing patients' quality of life and work efficiency, and imposing a significant economic burden on society. IVDD is defined by rapid extracellular matrix breakdown, nucleus pulposus cell loss, and an inflammatory response. It is intimately related to the malfunction or loss of myeloid cells among them. Many mechanisms have been implicated in the development of IVDD, including inflammatory factors, oxidative stress, apoptosis, cellular autophagy, and mitochondrial dysfunction. In recent years, mitochondrial dysfunction has become a hot research topic in age-related diseases. As the main source of adenosine triphosphate (ATP) in myeloid cells, mitochondria are essential for maintaining myeloid cell survival and physiological functions. We searched the PUBMED database with the search term "intervertebral disc degeneration and mitochondrial dysfunction" and obtained 82 articles, and after reading the abstracts and eliminating 30 irrelevant articles, we finally obtained 52 usable articles. Through a review of the literature, it was discovered that IVDD and cellular mitochondrial dysfunction are also linked. Mitochondrial dysfunction contributes to the advancement of IVDD by influencing a number of pathophysiologic processes such as mitochondrial fission/fusion, mitochondrial autophagy, cellular senescence, and cell death. We examine the molecular mechanisms of IVDD-associated mitochondrial dysfunction and present novel directions for quality management of mitochondrial dysfunction as a treatment approach to IVDD.
Identifiants
pubmed: 37925665
doi: 10.1007/s00011-023-01813-0
pii: 10.1007/s00011-023-01813-0
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2249-2260Subventions
Organisme : Luzhou's major scientific and technology research and development project
ID : 2022-SYF-42
Organisme : Luzhou Municipal People's Government - Southwest Medical University Science and Technology Strategic Cooperation Climbing Plan Project
ID : 2021LZXNYD-D02
Organisme : Joint Innovation Special of the Sichuan Provincial Science and Technology Plan
ID : 2022YFS0609/2022YFS0609-B3
Organisme : Sichuan Science and Technology Department Project Development Project
ID : 22ZDYF0512
Organisme : the Program for Special project of Traditional Chinese Medicine scientific research of Sichuan Science and Traditional Chinese Medicine Administration
ID : 2023MS019
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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