Net survival in colon and rectal cancer by stage according to neoadjuvant treatment. A French population-based study.

Clinical stage Colorectal cancer Pathological stage Population-based Survival

Journal

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
ISSN: 1878-3562
Titre abrégé: Dig Liver Dis
Pays: Netherlands
ID NLM: 100958385

Informations de publication

Date de publication:
03 Nov 2023
Historique:
received: 06 09 2023
revised: 11 10 2023
accepted: 13 10 2023
medline: 6 11 2023
pubmed: 6 11 2023
entrez: 5 11 2023
Statut: aheadofprint

Résumé

Real-life estimations of survival by stage in colorectal cancer are scanty. We estimated population-based net survival by pathological stage and location, and for rectal cancer by patterns of evolution according to clinical and pathological stage with regard to neoadjuvant therapy. Age-standardized net survival was estimated on 19,630 colorectal cancers diagnosed between 2009 and 2015. Five-year net survival was 64 % for colon and 62 % for rectal cancer. The highest absolute difference between colon and rectum was 12 % for stage II women aged 75 (91% vs. 79 %). Among patients with clinical stage III rectal cancer, 67 % no longer had pathological node involvement after neoadjuvant treatment. Survival was similar in clinical stage I, II or III and pathological stage III after neoadjuvant treatment and in pathological stage III without neoadjuvant treatment (between 67 % and 72 %). It ranged between 80 and 82 % in pathological stage II, without neoadjuvant treatment or with clinical stage I, II or III before neoadjuvant treatment. Survival ranged between 93 % and 95 % in pathological stage I, treated with surgery only or with clinical stage II or III before neoadjuvant treatment. Prognosis is associated with stage determined on surgical specimens rather than stage at the initial workup.

Identifiants

DOI: 10.1016/j.dld.2023.10.012 PMID: 37926634
pubmed: 37926634
pii: S1590-8658(23)01001-0
doi: 10.1016/j.dld.2023.10.012
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest None.

Auteurs

Valérie Jooste (V)

Digestive Cancer Registry of Burgundy, Dijon, France; Dijon University Hospital, Dijon, France; INSERM UMR 1231 EPICAD, Dijon, France; University of Burgundy, Dijon, France; FRANCIM Network, Toulouse F-31073, France.

Pascale Grosclaude (P)

FRANCIM Network, Toulouse F-31073, France; Tarn Cancer Registry, Claudius Regaud Institute, IUCT-O, Toulouse, France; CERPOP INSERM U1295, Toulouse III University, F-31000, France.

Gautier Defossez (G)

FRANCIM Network, Toulouse F-31073, France; Registre général des cancers de Poitou-Charentes, Poitiers University Hospital, France; INSERM Centre d'Investigation Clinique CIC1402, Poitiers, France.

Laetitia Daubisse (L)

FRANCIM Network, Toulouse F-31073, France; Tarn Cancer Registry, Claudius Regaud Institute, IUCT-O, Toulouse, France; CERPOP INSERM U1295, Toulouse III University, F-31000, France.

Anne-Sophie Woronoff (AS)

FRANCIM Network, Toulouse F-31073, France; Doubs Cancer Registry, Besançon University Hospital, Besançon, France; Research Unit EA3181, Franche-Comté University, Besançon, France.

Véronique Bouvier (V)

FRANCIM Network, Toulouse F-31073, France; ANTICIPE U1086 INSERM-UCN, Centre François Baclesse, Normandie UNICAEN university, Caen, France; Calvados Digestive Cancer Registry, University Hospital Centre, Caen, France.

Emmanuel Chirpaz (E)

FRANCIM Network, Toulouse F-31073, France; INSERM, CIC 1410, Reunion University Hospital, Saint-Pierre, France; Cancer Registry of Reunion Island, Reunion University Hospital, Saint-Denis, France.

Brigitte Tretarre (B)

FRANCIM Network, Toulouse F-31073, France; CERPOP INSERM U1295, Toulouse III University, F-31000, France; Registre des Tumeurs de l'Hérault, Montpellier, France.

Bénédicte Lapotre (B)

FRANCIM Network, Toulouse F-31073, France; Registre du cancer de la Somme, Amiens-Picardie University Hospital, Amiens, France; CHIMERE, Chirurgie, imagerie et régénération tissulaire de l'extrémité céphalique - Caractérisation morphologique et fonctionnelle, UR UPJV 7516, Amiens, France.

Sandrine Plouvier (S)

FRANCIM Network, Toulouse F-31073, France; Registre général des cancers de Lille et de sa région, GCS C2RC, Lille, France.

Guy Launoy (G)

FRANCIM Network, Toulouse F-31073, France; ANTICIPE U1086 INSERM-UCN, Centre François Baclesse, Normandie UNICAEN university, Caen, France; Calvados Digestive Cancer Registry, University Hospital Centre, Caen, France.

Mélanie Bonneault (M)

FRANCIM Network, Toulouse F-31073, France; Isere Cancer Registry, University Hospital Grenoble-Alpes, Grenoble, France.

Florence Molinié (F)

FRANCIM Network, Toulouse F-31073, France; CERPOP INSERM U1295, Toulouse III University, F-31000, France; Registre des Cancers de Loire-Atlantique et Vendee, Nantes University Hospital, France.

Anne-Marie Bouvier (AM)

Digestive Cancer Registry of Burgundy, Dijon, France; Dijon University Hospital, Dijon, France; INSERM UMR 1231 EPICAD, Dijon, France; University of Burgundy, Dijon, France; FRANCIM Network, Toulouse F-31073, France. Electronic address: anne-marie.bouvier@u-bourgogne.fr.

Classifications MeSH