Alzheimer's disease: an axonal injury disease?
APOE
Alzheimer’s disease
TREM2
amyloid-beta
axon
tau
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2023
2023
Historique:
received:
20
07
2023
accepted:
14
09
2023
medline:
6
11
2023
pubmed:
6
11
2023
entrez:
6
11
2023
Statut:
epublish
Résumé
Alzheimer's disease (AD) is the primary cause of dementia and is anticipated to impose a substantial economic burden in the future. Over a significant period, the widely accepted amyloid cascade hypothesis has guided research efforts, and the recent FDA approval of an anti- amyloid-beta (Aβ) protofibrils antibody, believed to decelerate AD progression, has further solidified its significance. However, the excessive emphasis placed on the amyloid cascade hypothesis has overshadowed the physiological nature of Aβ and tau proteins within axons. Axons, specialized neuronal structures, sustain damage during the early stages of AD, exerting a pivotal influence on disease progression. In this review, we present a comprehensive summary of the relationship between axonal damage and AD pathology, amalgamating the physiological roles of Aβ and tau proteins, along with the impact of AD risk genes such as APOE and TREM2. Furthermore, we underscore the exceptional significance of axonal damage in the context of AD.
Identifiants
pubmed: 37927337
doi: 10.3389/fnagi.2023.1264448
pmc: PMC10620718
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1264448Informations de copyright
Copyright © 2023 Dan and Zhang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Acta Neuropathol. 2018 Jul;136(1):57-67
pubmed: 29752551
Hum Mutat. 2009 Apr;30(4):E591-602
pubmed: 19263483
Neuron. 2018 Feb 21;97(4):823-835.e8
pubmed: 29398363
Sci Rep. 2016 Mar 15;6:23102
pubmed: 26976084
J Lipid Res. 2011 Mar;52(3):419-34
pubmed: 21062955
Mol Neurodegener. 2019 Jan 10;14(1):1
pubmed: 30630532
Neurosci Biobehav Rev. 2021 Jan;120:16-27
pubmed: 33188821
Acta Neuropathol Commun. 2016 Jul 19;4(1):74
pubmed: 27435172
Cold Spring Harb Perspect Biol. 2017 Jul 5;9(7):
pubmed: 28062563
Science. 2005 Jul 15;309(5733):476-81
pubmed: 16020737
Acta Neuropathol. 2017 May;133(5):665-704
pubmed: 28386764
Am J Pathol. 2017 Jul;187(7):1601-1612
pubmed: 28500862
Neurochem Int. 1992 Sep;21(2):177-83
pubmed: 1303150
Nature. 1994 Jun 9;369(6480):488-91
pubmed: 8202139
FEBS Lett. 2013 Jun 27;587(13):2036-45
pubmed: 23707420
Mol Neurodegener. 2012 Jun 18;7:29
pubmed: 22709375
BMC Genomics. 2013 Apr 30;14:290
pubmed: 23627794
Nat Med. 2012 Jan 29;18(2):291-5
pubmed: 22286308
Acta Neuropathol. 2020 Oct;140(4):417-447
pubmed: 32728795
Acta Neuropathol. 2021 Dec;142(6):951-960
pubmed: 34626223
Neurobiol Aging. 2010 Nov;31(11):1912-26
pubmed: 19091444
Front Neurosci. 2021 Oct 21;15:702788
pubmed: 34744602
Acta Neuropathol. 2021 Jun;141(6):841-859
pubmed: 33881612
Neuroimage. 2019 Apr 1;189:180-191
pubmed: 30630081
Mol Cell. 2022 Oct 6;82(19):3693-3711.e10
pubmed: 36108633
Acta Neuropathol. 2010 Mar;119(3):277-90
pubmed: 20155424
Mol Neurodegener. 2020 Jun 8;15(1):34
pubmed: 32513219
Lab Invest. 2019 Jul;99(7):912-928
pubmed: 30742061
Dementia. 1996 Mar-Apr;7(2):95-103
pubmed: 8866683
J Cell Biol. 2002 Aug 5;158(3):541-9
pubmed: 12163474
Glia. 2023 May;71(5):1247-1258
pubmed: 36625077
J Cell Biol. 2016 Nov 21;215(4):531-542
pubmed: 27872255
Autophagy. 2021 Jul;17(7):1796-1798
pubmed: 34085599
JAMA. 2023 Feb 7;329(5):363
pubmed: 36652625
Acta Neuropathol. 2021 Feb;141(2):257-279
pubmed: 33398403
Cell Metab. 2020 Mar 3;31(3):623-641.e8
pubmed: 32130884
Biochem Pharmacol. 2014 Apr 15;88(4):517-28
pubmed: 24412275
Nat Cell Biol. 2019 Jan;21(1):63-71
pubmed: 30602761
CNS Neurosci Ther. 2020 Jul;26(7):698-710
pubmed: 32115899
Cell. 2014 Nov 6;159(4):766-74
pubmed: 25417154
Acta Neuropathol. 2017 May;133(5):717-730
pubmed: 28091722
EMBO J. 2018 Apr 3;37(7):
pubmed: 29472250
Neuron. 2016 Nov 23;92(4):845-856
pubmed: 27773584
Acta Neuropathol. 2015 Jan;129(1):21-37
pubmed: 25432317
Curr Biol. 2018 Jul 9;28(13):2181-2189.e4
pubmed: 30008334
J Neurosci. 2017 Mar 8;37(10):2639-2655
pubmed: 28159908
Nat Med. 2018 Mar;24(3):313-325
pubmed: 29400714
Science. 2018 Aug 10;361(6402):604-607
pubmed: 29976799
Nat Genet. 2003 Mar;33(3):366-74
pubmed: 12590258
Genome Biol. 2005;6(1):204
pubmed: 15642108
Nature. 2017 Jul 13;547(7662):236-240
pubmed: 28636604
Neurology. 2005 May 10;64(9):1502-7
pubmed: 15883308
Annu Rev Genet. 2021 Nov 23;55:93-113
pubmed: 34351802
Nature. 2019 Jun;570(7761):332-337
pubmed: 31042697
Biochem Soc Trans. 2011 Aug;39(4):933-8
pubmed: 21787326
Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11597-11602
pubmed: 27671637
Nat Commun. 2017 May 11;8:15295
pubmed: 28492240
Nat Neurosci. 2009 Dec;12(12):1567-76
pubmed: 19935655
J Clin Invest. 2023 Jun 1;133(11):
pubmed: 37259916
Trends Pharmacol Sci. 2016 May;37(5):390-411
pubmed: 26837733
Mol Cell. 2018 Oct 4;72(1):19-36.e8
pubmed: 30244836
Science. 1998 Jun 5;280(5369):1610-3
pubmed: 9616125
Nat Cell Biol. 2019 Sep;21(9):1078-1085
pubmed: 31481790
J Neurosci. 2023 Mar 8;43(10):1830-1844
pubmed: 36717226
Front Cell Neurosci. 2015 Aug 07;9:297
pubmed: 26300732
Aging Cell. 2019 Jun;18(3):e12932
pubmed: 30884121
Front Neurosci. 2017 Sep 04;11:451
pubmed: 28928628
J Exp Med. 2021 Oct 4;218(10):
pubmed: 34424266
J Exp Med. 2016 May 2;213(5):667-75
pubmed: 27091843
Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5237-45
pubmed: 26351690
J Cell Biol. 2000 Sep 4;150(5):989-1000
pubmed: 10973990
Neuron. 2021 May 19;109(10):1657-1674.e7
pubmed: 33831349
Front Aging Neurosci. 2020 Oct 15;12:581767
pubmed: 33192476
Neuron. 2023 May 17;111(10):1577-1590.e11
pubmed: 36948206
Arch Neurol. 1999 Mar;56(3):338-44
pubmed: 10190825
J Biomed Sci. 2017 Sep 19;24(1):76
pubmed: 28927401
J Neurosci. 2017 Jan 18;37(3):637-647
pubmed: 28100745
J Am Heart Assoc. 2016 Feb 12;5(2):
pubmed: 26873692
J Cell Biol. 2015 Aug 17;210(4):529-39
pubmed: 26283796
PLoS Biol. 2017 Jul 6;15(7):e2002183
pubmed: 28683104
J Clin Invest. 2015 Jan;125(1):65-74
pubmed: 25654552
Nat Rev Neurol. 2019 Sep;15(9):501-518
pubmed: 31367008
Nat Genet. 2017 Sep;49(9):1373-1384
pubmed: 28714976
Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4656-61
pubmed: 10200318
Proc Natl Acad Sci U S A. 1985 Nov;82(22):7716-20
pubmed: 2415969
Cell. 2017 Aug 10;170(4):649-663.e13
pubmed: 28802038
Neuron. 2014 Jun 18;82(6):1271-88
pubmed: 24857020
JAMA Neurol. 2020 Feb 1;77(2):215-224
pubmed: 31710340
J Neurochem. 2014 Jan;128(1):196-204
pubmed: 23919582
Cell Rep. 2016 Sep 13;16(11):2889-2900
pubmed: 27626660
J Neurosci. 1998 Mar 15;18(6):1953-62
pubmed: 9482781
J Biol Chem. 2016 Apr 8;291(15):8173-88
pubmed: 26861879
BMC Genomics. 2016 Mar 31;17:264
pubmed: 27030133
Nature. 2021 Oct;598(7880):359-363
pubmed: 34588692
Neurocase. 2018 Jun;24(3):140-144
pubmed: 29969053
J Neurosci. 2018 Jan 10;38(2):291-307
pubmed: 29167405
Front Neurosci. 2021 Sep 21;15:734001
pubmed: 34621153
Dev Neurobiol. 2014 Aug;74(8):797-817
pubmed: 23818454
J Cell Biol. 2018 Feb 5;217(2):459-472
pubmed: 29196460
J Med Chem. 2012 Nov 8;55(21):8979-96
pubmed: 23020671
Nat Rev Neurosci. 2017 May;18(5):281-298
pubmed: 28360418
JAMA Neurol. 2019 Nov 01;76(11):1298-1308
pubmed: 31380975
Cell. 2016 Aug 25;166(5):1163-1175.e12
pubmed: 27565345
Sci Rep. 2019 Apr 25;9(1):6555
pubmed: 31024073
Trends Cell Biol. 2019 Jun;29(6):452-461
pubmed: 30929793
J Exp Med. 2015 Mar 9;212(3):287-95
pubmed: 25732305
Physiol Rev. 2011 Apr;91(2):555-602
pubmed: 21527732
Neuron. 2023 Jul 19;111(14):2170-2183.e6
pubmed: 37192625
Trends Neurosci. 2017 Jun;40(6):347-357
pubmed: 28494972
Autophagy. 2012 Nov;8(11):1686-7
pubmed: 22874558
Sci Rep. 2020 Sep 8;10(1):14776
pubmed: 32901091
Eur J Pharmacol. 2006 Sep 1;545(1):11-21
pubmed: 16887118
N Engl J Med. 2023 Jan 5;388(1):9-21
pubmed: 36449413
Front Aging Neurosci. 2017 Oct 31;9:345
pubmed: 29163128
Neuron. 2020 Jan 22;105(2):276-292.e5
pubmed: 31786011
Alzheimers Dement. 2022 May;18(5):988-1007
pubmed: 34581500
Ageing Res Rev. 2021 Jan;65:101208
pubmed: 33157321
Acta Neuropathol Commun. 2017 Jun 7;5(1):41
pubmed: 28587664
Lancet Neurol. 2021 Jan;20(1):68-80
pubmed: 33340485
Cell Rep. 2021 Oct 19;37(3):109855
pubmed: 34686344
Alzheimers Dement. 2022 Dec;18(12):2527-2536
pubmed: 35174954
Neurobiol Aging. 2007 Nov;28(11):1689-99
pubmed: 16963164
Cell. 2020 Jun 11;181(6):1207-1217
pubmed: 32531244
J Cell Sci. 2001 Mar;114(Pt 6):1179-87
pubmed: 11228161
Nat Neurosci. 2019 Feb;22(2):191-204
pubmed: 30617257
Acta Neuropathol. 2006 Oct;112(4):389-404
pubmed: 16906426
Diabetologia. 1991 Jun;34(6):387-9
pubmed: 1715829
Dev Neurobiol. 2014 Dec;74(12):1210-25
pubmed: 24909306
Exp Neurol. 2012 Jan;233(1):364-72
pubmed: 22079153
Nat Commun. 2019 Jul 2;10(1):2909
pubmed: 31266957
J Cell Biol. 2001 Oct 1;155(1):65-76
pubmed: 11581286
Acta Neuropathol. 2010 Nov;120(5):593-604
pubmed: 20617325
Nat Med. 2021 Sep;27(9):1592-1599
pubmed: 34446931
Acta Neuropathol. 2021 Feb;141(2):173-192
pubmed: 33427938
J Neurosci. 2014 May 21;34(21):7124-36
pubmed: 24849348
J Neurosci. 2015 Apr 15;35(15):6221-30
pubmed: 25878292
Biochimie. 2016 Nov;130:178-187
pubmed: 27594339
Proc Natl Acad Sci U S A. 1982 Nov;79(21):6546-50
pubmed: 6959136
J Neuroinflammation. 2017 Jun 8;14(1):116
pubmed: 28595650
Hum Mol Genet. 2016 Jun 15;25(12):2378-2392
pubmed: 27056981
Hum Mol Genet. 2015 Jul 1;24(13):3623-37
pubmed: 25794683
Front Mol Neurosci. 2017 Nov 17;10:382
pubmed: 29204109
Neurology. 2018 Jul 24;91(4):e313-e318
pubmed: 29959265
J Neuropathol Exp Neurol. 2011 Nov;70(11):960-9
pubmed: 22002422
Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11324-11329
pubmed: 27638205
Nat Rev Neurosci. 2014 Jun;15(6):394-409
pubmed: 24840802
Acta Neuropathol Commun. 2015 Mar 24;3:14
pubmed: 25853174
Nature. 2023 Jun;618(7964):349-357
pubmed: 37258678
Nat Neurosci. 2019 Jun;22(6):851-862
pubmed: 31086314
Autophagy. 2012 Apr;8(4):609-22
pubmed: 22361619
Int J Mol Sci. 2020 Jun 08;21(11):
pubmed: 32521826
EMBO Mol Med. 2020 Apr 7;12(4):e11227
pubmed: 32154671
Nat Rev Neurosci. 2020 Jan;21(1):21-35
pubmed: 31780819
Mol Psychiatry. 2022 Jul;27(7):3010-3023
pubmed: 35393558
Trends Biochem Sci. 2009 Jul;34(7):332-42
pubmed: 19559622
J Clin Invest. 2020 May 1;130(5):2220-2236
pubmed: 32202512
Chem Soc Rev. 2022 Jan 24;51(2):513-565
pubmed: 34889934
Neuroimage. 2017 Oct 15;160:32-40
pubmed: 28159687
Int J Mol Sci. 2018 Mar 06;19(3):
pubmed: 29509687
Nature. 2022 Nov;611(7937):769-779
pubmed: 36385529
J Alzheimers Dis. 2017;59(2):405-419
pubmed: 28527209
Neurobiol Dis. 2022 Apr;165:105630
pubmed: 35041990
Neuroscience. 2013 May 15;238:258-69
pubmed: 23485808
Mol Neurobiol. 2021 May;58(5):2183-2201
pubmed: 33411241
Mol Biol Cell. 2016 Oct 1;27(19):2924-34
pubmed: 27466319
Nat Genet. 2019 Mar;51(3):414-430
pubmed: 30820047
Acta Neuropathol. 2020 Oct;140(4):513-534
pubmed: 32772264
Nat Genet. 2019 Mar;51(3):404-413
pubmed: 30617256
Nature. 1990 Feb 1;343(6257):461-3
pubmed: 2105469
Radiology. 2022 Jan;302(1):143-150
pubmed: 34636637
J Neurosci. 2013 Jul 31;33(31):12887-97
pubmed: 23904623
Science. 2008 Feb 22;319(5866):1086-9
pubmed: 18202255
Neuron. 2017 Mar 8;93(5):1015-1034
pubmed: 28279350
EMBO J. 2011 Oct 18;30(23):4825-37
pubmed: 22009197
Acta Neuropathol. 1989;78(1):47-51
pubmed: 2735189
Alzheimers Dement. 2021 Jan;17(1):89-102
pubmed: 32920988
Cell Rep. 2022 May 3;39(5):110776
pubmed: 35508140
Mol Neurodegener. 2022 Feb 2;17(1):13
pubmed: 35109920
Mol Neurodegener. 2011 Aug 26;6(1):63
pubmed: 21871088
Brain. 2021 Dec 16;144(11):3371-3380
pubmed: 34515756
Mol Neurodegener. 2018 Nov 7;13(1):59
pubmed: 30404654
Int J Mol Sci. 2023 Mar 31;24(7):
pubmed: 37047532
Trends Cell Biol. 2023 Jul 13;:
pubmed: 37453878
Curr Biol. 2021 May 24;31(10):R633-R650
pubmed: 34033795
Lancet Neurol. 2019 Jul;18(7):684-696
pubmed: 31097385
Nat Med. 2011 Apr;17(4):495-9
pubmed: 21441916
Semin Cell Dev Biol. 2023 Apr;139:13-23
pubmed: 35690535
Diabetes. 1997 Dec;46(12):2057-62
pubmed: 9392496
Alzheimers Dement. 2023 Apr;19(4):1598-1695
pubmed: 36918389
J Neuropathol Exp Neurol. 2009 Jul;68(7):757-61
pubmed: 19535996
Alzheimers Dement. 2023 Apr;19(4):1503-1517
pubmed: 36047604
Nat Rev Neurol. 2023 Jan;19(1):19-38
pubmed: 36513730
Cell Rep. 2017 Sep 5;20(10):2304-2312
pubmed: 28877466
Neurobiol Dis. 2013 Jul;55:129-39
pubmed: 23523634
J Med Chem. 2021 Jan 28;64(2):1073-1102
pubmed: 33411523
Mol Psychiatry. 2011 Sep;16(9):908-16
pubmed: 20820167
EMBO J. 2018 Jun 1;37(11):
pubmed: 29661886
Neuron. 2019 Nov 6;104(3):458-470.e5
pubmed: 31542321
J Exp Med. 2020 Sep 7;217(9):
pubmed: 32579671
Proc Natl Acad Sci U S A. 2000 May 23;97(11):6037-42
pubmed: 10811879
J Neurosci. 2019 May 15;39(20):3832-3844
pubmed: 30850513
Elife. 2016 Aug 08;5:
pubmed: 27501441
Science. 2019 Oct 11;366(6462):
pubmed: 31601744
Neuron. 2015 May 20;86(4):985-999
pubmed: 25959733
Annu Rev Pathol. 2019 Jan 24;14:239-261
pubmed: 30355155
Neuron. 2021 Mar 3;109(5):767-777.e5
pubmed: 33472038
Mol Neurodegener. 2016 Jun 29;11(1):47
pubmed: 27356871
Neurobiol Aging. 2018 May;65:235-238
pubmed: 29580440
Nat Commun. 2017 Aug 17;8(1):275
pubmed: 28819146
Eur J Epidemiol. 2022 Jun;37(6):591-601
pubmed: 35471691
Brain. 2018 Mar 1;141(3):888-902
pubmed: 29309541