Pulmonary Hypertension Is Associated with Worse Outcomes in Patients Hospitalized for Sick Sinus Syndrome.
Cardiac arrest
cardiogenic shock
pacemaker insertion
pulmonary hypertension
sick sinus syndrome
Journal
The Journal of innovations in cardiac rhythm management
ISSN: 2156-3977
Titre abrégé: J Innov Card Rhythm Manag
Pays: United States
ID NLM: 101589872
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
12
03
2023
accepted:
31
05
2023
medline:
6
11
2023
pubmed:
6
11
2023
entrez:
6
11
2023
Statut:
epublish
Résumé
Sick sinus syndrome (SSS) is a condition of the sinoatrial node that arises from a constellation of aberrant rhythms, resulting in reduced pacemaker activity and impulse transmission. According to the World Health Organization, pulmonary hypertension (PH) is defined by a mean pulmonary arterial pressure of >25 mmHg at rest, measured during right heart catheterization. It can result in right atrial remodeling, which may predispose the patient to sinus node dysfunction. This study sought to estimate the impact of PH on clinical outcomes of hospitalizations with SSS. The U.S. National Inpatient Sample database from 2016-2019 was searched for hospitalized adult patients with SSS as a principal diagnosis with and without PH as a secondary diagnosis using the International Classification of Diseases, Tenth Revision, codes. The primary outcome was inpatient mortality. The secondary outcomes were acute kidney injury (AKI), cardiogenic shock (CS), cardiac arrest, rates of pacemaker insertion, total hospital charges (THCs), and length of stay (LOS). Multivariate regression analysis was used to adjust for confounders. A total of 181,230 patients were admitted for SSS; 8.3% (14,990) had underlying PH. Compared to patients without PH, patients admitted with coexisting PH had a statistically significant increase in mortality (95% confidence interval, 1.21-2.32;
Identifiants
pubmed: 37927394
doi: 10.19102/icrm.2023.14105
pii: icrm.2023.14105
pmc: PMC10621623
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5622-5628Informations de copyright
Copyright: © 2023 Innovations in Cardiac Rhythm Management.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest for the published content. No funding information was provided.
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