Pigmented skin exhibits accelerated wound healing compared to the nonpigmented skin in Guinea pig model.
Biological sciences
Cell biology
Histology
Molecular biology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
17 Nov 2023
17 Nov 2023
Historique:
received:
01
03
2023
revised:
25
08
2023
accepted:
05
10
2023
medline:
6
11
2023
pubmed:
6
11
2023
entrez:
6
11
2023
Statut:
epublish
Résumé
This study investigated and compared the wound healing kinetics of pigmented (PG) and non-pigmented (NP) skin in guinea pigs, focusing on histological and transcriptional changes. Full-thickness wounds created on PG and NP skin were evaluated at various time points post-injury. Fontana-Masson staining and ultrastructural analysis suggested the presence of melanin and melanosomes in PG skin, which coincided with an upregulation of melanogenic genes cKIT, TYR, and DCT. On day 9 post-wound, PG skin exhibited a rapid transition from the inflammatory to proliferative phase, which correlated with the reappearance of epidermal pigmentation whereas the NP skin exhibited a delayed neo-epidermis formation. Furthermore, the study revealed that melanocyte-derived growth factors (conditioned media) positively regulated keratinocyte migration while inhibiting fibroblast differentiation. These effects were more prominent in tyrosine-treated (hyperpigmented) melanocyte-CM as was TGF- β expression. These findings provide valuable insights into the mechanisms underlying skin repair and pigmentation.
Identifiants
pubmed: 37927554
doi: 10.1016/j.isci.2023.108159
pii: S2589-0042(23)02236-8
pmc: PMC10622689
doi:
Types de publication
Journal Article
Langues
eng
Pagination
108159Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
R.S.G. is a co-founder of Vyome Biosciences Pvt. Ltd., a biopharmaceutical company working in the dermatology area.
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