Effects of deep brain stimulation of the subthalamic nucleus on patients with Parkinson's disease: a machine-learning voice analysis.
Parkinson's disease
deep brain stimulation
machine-learning
subthalamic nucleus
voice analysis
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2023
2023
Historique:
received:
26
07
2023
accepted:
20
09
2023
medline:
6
11
2023
pubmed:
6
11
2023
entrez:
6
11
2023
Statut:
epublish
Résumé
Deep brain stimulation of the subthalamic nucleus (STN-DBS) can exert relevant effects on the voice of patients with Parkinson's disease (PD). In this study, we used artificial intelligence to objectively analyze the voices of PD patients with STN-DBS. In a cross-sectional study, we enrolled 108 controls and 101 patients with PD. The cohort of PD was divided into two groups: the first group included 50 patients with STN-DBS, and the second group included 51 patients receiving the best medical treatment. The voices were clinically evaluated using the Unified Parkinson's Disease Rating Scale part-III subitem for voice (UPDRS-III-v). We recorded and then analyzed voices using specific machine-learning algorithms. The likelihood ratio (LR) was also calculated as an objective measure for clinical-instrumental correlations. Clinically, voice impairment was greater in STN-DBS patients than in those who received oral treatment. Using machine learning, we objectively and accurately distinguished between the voices of STN-DBS patients and those under oral treatments. We also found significant clinical-instrumental correlations since the greater the LRs, the higher the UPDRS-III-v scores. STN-DBS deteriorates speech in patients with PD, as objectively demonstrated by machine-learning voice analysis.
Identifiants
pubmed: 37928137
doi: 10.3389/fneur.2023.1267360
pmc: PMC10622670
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1267360Investigateurs
Maria Concetta Altavista
(MC)
Alessandra Calciulli
(A)
Marco Ciavarro
(M)
Francesca Cortese
(F)
Antonio Daniele
(A)
Alessandro De Biase
(A)
Manuela D'Ercole
(M)
Lazzaro Di Biase
(LD)
Daniela Di Giuda
(DD)
Pietro Di Leo
(PD)
Danilo Genovese
(D)
Isabella Imbimbo
(I)
Alessandro Izzo
(A)
Rosa Liperoti
(R)
Giuseppe Marano
(G)
Massimo Marano
(M)
Marianna Mazza
(M)
Alessandra Monge
(A)
Nicola Montano
(N)
Michela Orsini
(M)
Leonardo Rigon
(L)
Marina Rizz
(M)
Camilla Rocchi
(C)
Gennaro Saporito
(G)
Laura Vacca
(L)
Fabio Viselli
(F)
Informations de copyright
Copyright © 2023 Suppa, Asci, Costantini, Bove, Piano, Pistoia, Cerroni, Brusa, Cesarini, Pietracupa, Modugno, Zampogna, Sucapane, Pierantozzi, Tufo, Pisani, Peppe, Stefani, Calabresi, Bentivoglio, Saggio and Lazio DBS Study Group.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
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