A case of marked rectal stenosis due to Douglas' pouch metastasis of renal pelvic carcinoma successfully treated with salvage enfortumab vedotin: correlation between serum KL-6 levels and tumor response.
KL‐6
biomarker
rectal stenosis
renal pelvic urothelial carcinoma
Journal
IJU case reports
ISSN: 2577-171X
Titre abrégé: IJU Case Rep
Pays: Australia
ID NLM: 101764958
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
23
06
2023
accepted:
13
09
2023
medline:
6
11
2023
pubmed:
6
11
2023
entrez:
6
11
2023
Statut:
epublish
Résumé
We report a rare case of marked rectal stenosis due to Douglas' pouch metastasis of renal pelvic urothelial carcinoma successfully treated with enfortumab vedotin. A 77-year-old female presented with difficulty in defecation and abdominal distension. She had received two courses of cisplatin plus gemcitabine followed by four courses of maintenance avelumab for postoperative lymph node metastasis of renal pelvic urothelial carcinoma. KL-6 levels were elevated, and a computed tomography scan revealed an irregularly shaped large mass occupying Douglas' pouch, with marked rectal stenosis. Metastatic urothelial carcinoma was pathologically diagnosed, and enfortumab vedotin was initiated after colostomy. After 12 courses of enfortumab vedotin, metastatic lesions showed marked shrinkage and KL-6 levels decreased. Enfortumab vedotin elicited a remarkable response in treating rectal stenosis due to metastasis of renal pelvic urothelial carcinoma in Douglas' pouch. Furthermore, serum KL-6 levels were correlated with the severity of metastatic urothelial carcinoma.
Identifiants
pubmed: 37928289
doi: 10.1002/iju5.12645
pii: IJU512645
pmc: PMC10622197
doi:
Types de publication
Case Reports
Langues
eng
Pagination
449-453Informations de copyright
© 2023 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Urological Association.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Comput Assist Tomogr. 2011 Mar-Apr;35(2):217-22
pubmed: 21412093
N Engl J Med. 2021 Mar 25;384(12):1125-1135
pubmed: 33577729
Arthritis Res Ther. 2019 Feb 14;21(1):58
pubmed: 30764869
Med Mol Morphol. 2009 Jun;42(2):123-7
pubmed: 19536620
J Clin Oncol. 2020 Apr 1;38(10):1041-1049
pubmed: 32031899
Int J Surg Case Rep. 2021 May;82:105785
pubmed: 33865196
PLoS One. 2014 Mar 26;9(3):e92742
pubmed: 24671186
Am J Physiol Lung Cell Mol Physiol. 2004 Jun;286(6):L1088-94
pubmed: 12959931
BJU Int. 2011 Apr;107(7):1059-64
pubmed: 20825397
Urol Case Rep. 2021 Aug 30;39:101833
pubmed: 34504777