Local application of engineered insulin-like growth factor I mRNA demonstrates regenerative therapeutic potential
IGF-I
MT: RNA/DNA Editing
disc herniation
mRNA therapy
muscle injury
regeneration
Journal
Molecular therapy. Nucleic acids
ISSN: 2162-2531
Titre abrégé: Mol Ther Nucleic Acids
Pays: United States
ID NLM: 101581621
Informations de publication
Date de publication:
12 Dec 2023
12 Dec 2023
Historique:
received:
27
04
2023
accepted:
11
10
2023
medline:
6
11
2023
pubmed:
6
11
2023
entrez:
6
11
2023
Statut:
epublish
Résumé
Insulin-like growth factor I (IGF-I) is a growth-promoting anabolic hormone that fosters cell growth and tissue homeostasis. IGF-I deficiency is associated with several diseases, including growth disorders and neurological and musculoskeletal diseases due to impaired regeneration. Despite the vast regenerative potential of IGF-I, its unfavorable pharmacokinetic profile has prevented it from being used therapeutically. In this study, we resolved these challenges by the local administration of IGF-I mRNA, which ensures desirable homeostatic kinetics and non-systemic, local dose-dependent expression of IGF-I protein. Furthermore, IGF-I mRNA constructs were sequence engineered with heterologous signal peptides, which improved
Identifiants
pubmed: 37928443
doi: 10.1016/j.omtn.2023.102055
pii: S2162-2531(23)00273-1
pmc: PMC10622308
doi:
Types de publication
Journal Article
Langues
eng
Pagination
102055Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
Versameb AG is a privately held company focusing on discovering and developing innovative RNA-based drugs based in Basel, Switzerland. All authors affiliated with Versameb AG were employees during the course of this work and equity holders of Versameb.
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