The lymphatic system: a pathway for meta-inflammation in permafrost immunity.
Lymphatics
inflamm-aging
meta-inflammation
pandemic
permafrost pathogens
pro-inflammatory cytokines
public health
Journal
Bioinformation
ISSN: 0973-2063
Titre abrégé: Bioinformation
Pays: Singapore
ID NLM: 101258255
Informations de publication
Date de publication:
2023
2023
Historique:
received:
01
09
2023
revised:
30
09
2023
accepted:
30
09
2023
medline:
6
11
2023
pubmed:
6
11
2023
entrez:
6
11
2023
Statut:
epublish
Résumé
The lymphatic system is the anatomical substratum of immunity. Lymphatics collect tissue exudates, which contain cell debris, peptides, micronutrients and pathogens, as well as immune naive and memory effector cells from the body tissues and organs into the lymph. Lined by endothelial cells cemented together by tight junctions to ensure their impermeability, lymphatics contain valves that prevent the backward flow of the lymph as it moves forward toward the right and left venous angles, the anatomical site of confluence with the venous blood. Meta-inflammation increases the permeability of lymphatics, rendering the elderly more susceptible to novel and ancient airborne viruses released by melting glaciers and permafrost. Simple public health protocols (e.g., mask-wearing, quarantine) are essential to minimize colliding epidemics/pandemics, and favor permafrost immunity.
Identifiants
pubmed: 37928496
doi: 10.6026/97320630019886
pii: 97320630019886
pmc: PMC10625371
doi:
Types de publication
Editorial
Langues
eng
Pagination
886-888Informations de copyright
© 2023 Biomedical Informatics.
Références
Cytokine. 2013 Oct;64(1):362-9
pubmed: 23764549
Emerg Infect Dis. 2022 Feb;28(2):273-281
pubmed: 35075991
Angiogenesis. 2014 Apr;17(2):395-406
pubmed: 24141404
Bioinformation. 2022 Sep 30;18(9):768-773
pubmed: 37426505
J Neurosci. 2021 Sep 15;41(37):7698-7711
pubmed: 34526407
Bioinformation. 2022 Sep 30;18(9):734-738
pubmed: 37426494
Cells. 2021 Nov 12;10(11):
pubmed: 34831371
PLoS One. 2016 Jul 06;11(7):e0158839
pubmed: 27383632
Clin Rev Allergy Immunol. 2023 Apr;64(2):109-122
pubmed: 34536213
Aging (Albany NY). 2019 Aug 28;11(16):6602-6613
pubmed: 31461408
Bioinformation. 2023 Mar 31;19(3):251-254
pubmed: 37808373
Front Immunol. 2019 May 10;10:1071
pubmed: 31134099