Single nucleotide polymorphisms in vitamin D binding protein and 25-hydroxylase genes affect vitamin D levels in adolescents of Arab ethnicity in Kuwait.
Adolescent
Humans
Arabs
/ genetics
Cholestanetriol 26-Monooxygenase
/ genetics
Ethnicity
Kuwait
/ epidemiology
Mixed Function Oxygenases
/ genetics
Polymorphism, Single Nucleotide
Vitamin D
Vitamin D Deficiency
/ epidemiology
Vitamin D-Binding Protein
/ genetics
Vitamins
Cytochrome P450 Family 2
/ genetics
Arab ethnicity
CYP2R1
GC globular gene
single nucleotide polymorphism
vitamin D binding protein
vitamin D deficiency
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2023
2023
Historique:
received:
11
07
2023
accepted:
09
10
2023
medline:
7
11
2023
pubmed:
6
11
2023
entrez:
6
11
2023
Statut:
epublish
Résumé
Vitamin D deficiency (VDD) is widespread in the Arab world despite ample sunshine throughout the year. In our previous study, lifestyle and socio-demographic factors could explain only 45% of variability in vitamin D levels in Kuwaiti adolescents, suggesting that genetics might contribute to VDD in this region. Single nucleotide polymorphisms (SNP) in the 25-hydroxylase (
Identifiants
pubmed: 37929021
doi: 10.3389/fendo.2023.1257051
pmc: PMC10623322
doi:
Substances chimiques
Cholestanetriol 26-Monooxygenase
EC 1.14.15.15
Mixed Function Oxygenases
EC 1.-
Vitamin D
1406-16-2
Vitamin D-Binding Protein
0
Vitamins
0
CYP2R1 protein, human
EC 1.14.14.24
Cytochrome P450 Family 2
EC 1.14.14.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1257051Informations de copyright
Copyright © 2023 Rahman, Abu-Farha, Channanath, Hammad, Anoop, Chandy, Melhem, Al-Mulla, Thanaraj and Abubaker.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
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