Molecular interplay between ecdysone receptor and retinoid X receptor in regulating the molting of the Chinese mitten crab,
ecdysone receptor
ecdysteroid signaling pathway
molecular interplay
molting
retinoid X receptor
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2023
2023
Historique:
received:
02
07
2023
accepted:
05
10
2023
medline:
7
11
2023
pubmed:
6
11
2023
entrez:
6
11
2023
Statut:
epublish
Résumé
Molting is a pivotal biological process regulated by the ecdysteroid signaling pathway that requires molecular coordination of two transcription factors, Ecdysone receptor (EcR) and ultraspiracle (USP) in arthropods. However, the molecular interplay of EcR and Retinoid X receptor (RXR), the crustacean homolog of USP in the ecdysteroid signaling pathway, is not well understood. In this study, we conducted temporal and spatial expression, co-immunoprecipitation (CO-IP), and luciferase reporter assay experiments to investigate the molecular function and interplay of EcR and RXR during the molting process of the Chinese mitten crab, The results showed that the expression level of Our study unveiled the diverse molecular function and molecular interplay of EcR and RXR;
Identifiants
pubmed: 37929030
doi: 10.3389/fendo.2023.1251723
pmc: PMC10621794
doi:
Substances chimiques
ecdysone receptor
0
Retinoid X Receptors
0
Ecdysteroids
0
Luciferases
EC 1.13.12.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1251723Informations de copyright
Copyright © 2023 Chen, Hou, Yang, Liu, Wang and Wang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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