Genetic analysis of the equine orthologues for human CYP2D6: unraveling the complexity of the CYP2D family in horses.
CYP2D50
CYP2D6 equine orthologues
CYP2D82
drug metabolism
horse pharmacogenetics
Journal
Frontiers in veterinary science
ISSN: 2297-1769
Titre abrégé: Front Vet Sci
Pays: Switzerland
ID NLM: 101666658
Informations de publication
Date de publication:
2023
2023
Historique:
received:
17
03
2023
accepted:
25
09
2023
medline:
6
11
2023
pubmed:
6
11
2023
entrez:
6
11
2023
Statut:
epublish
Résumé
Because of their importance as companion animals or as racehorses, horses can be treated with various drugs. Although it is known that drug withdrawal times can vary for each horse, pharmacogenetics for these animals has not been adequately studied and requires further development. Since Genomic DNA extracted from venous blood and mRNA from fresh liver tissue were amplified and sequenced to analyze the genomic structure, genotype, and expression of the various enzymes that are part of the equine orthologous family for Amplification and sequencing of the gDNA of This study aimed to elucidate the pharmacogenetic analysis of the
Identifiants
pubmed: 37929279
doi: 10.3389/fvets.2023.1188633
pmc: PMC10620600
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1188633Informations de copyright
Copyright © 2023 Scantamburlo, Nofziger, Paulmichl and Vanoni.
Déclaration de conflit d'intérêts
GS, CN and SV are employees of PharmGenetix GmbH. MP is employed by Privatklinik Maria Hilf GmbH.
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