Somatic mutation burden in relation to aging and functional life span: implications for cellular reprogramming and rejuvenation.
Journal
Current opinion in genetics & development
ISSN: 1879-0380
Titre abrégé: Curr Opin Genet Dev
Pays: England
ID NLM: 9111375
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
05
07
2023
revised:
02
09
2023
accepted:
07
10
2023
medline:
5
12
2023
pubmed:
7
11
2023
entrez:
6
11
2023
Statut:
ppublish
Résumé
The accrual of somatic mutations has been implicated as causal factors in aging since the 1950s. However, the quantitative analysis of somatic mutations has posed a major challenge due to the random nature of de novo mutations in normal tissues, which has limited analysis to tumors and other clonal lineages. Advances in single-cell and single-molecule next-generation sequencing now allow to obtain, for the first time, detailed insights into the landscape of somatic mutations in different human tissues and cell types as a function of age under various conditions. Here, we will briefly recapitulate progress in somatic mutation analysis and discuss the possible relationship between somatic mutation burden with functional life span, with a focus on differences between germ cells, stem cells, and differentiated cells.
Identifiants
pubmed: 37931583
pii: S0959-437X(23)00112-0
doi: 10.1016/j.gde.2023.102132
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102132Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest Alexander Maslov and Jan Vijg are co-founders of SingulOmics Corp and Mutagentech Corp.