Amorphization of different furosemide polymorphic forms during ball milling: Tracking solid-to-solid phase transformations.
Amorphous form
Amorphous relaxation
Ball milling
Furosemide
Glass transition temperature
Polymorphs
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
15 Dec 2023
15 Dec 2023
Historique:
received:
11
07
2023
revised:
02
11
2023
accepted:
02
11
2023
medline:
5
12
2023
pubmed:
7
11
2023
entrez:
6
11
2023
Statut:
ppublish
Résumé
Ball milling is used, not only to reduce the particle size of pharmaceutical powders, but also to induce changes in the physical properties of drugs. In this work we prepared three crystal forms of furosemide (forms Ⅰ, Ⅱ, and Ⅲ) and studied their solid phase transformations during ball milling. Powder X-ray diffraction and modulated differential scanning calorimetry were used to characterize the samples after each milling time on their path to amorphization. Our results show that forms Ⅰ and III directly converted into an amorphous phase, while form Ⅱ first undergoes a polymorphic transition to form Ⅰ, and then gradually loses its crystallinity, finally reaching full amorphousness. During ball milling of forms Ⅰ and Ⅱ, the glass transition temperature (T
Identifiants
pubmed: 37931725
pii: S0378-5173(23)00994-8
doi: 10.1016/j.ijpharm.2023.123573
pii:
doi:
Substances chimiques
Furosemide
7LXU5N7ZO5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
123573Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.