Association between the skin microbiome and MHC class II diversity in an amphibian.
Rana arvalis
MHC IIB
MHC class II beta chain
bacterial diversity
host-associated microbiome
Journal
Molecular ecology
ISSN: 1365-294X
Titre abrégé: Mol Ecol
Pays: England
ID NLM: 9214478
Informations de publication
Date de publication:
07 Nov 2023
07 Nov 2023
Historique:
revised:
20
10
2023
received:
03
04
2023
accepted:
26
10
2023
medline:
7
11
2023
pubmed:
7
11
2023
entrez:
7
11
2023
Statut:
aheadofprint
Résumé
Microbiomes play an important role in determining the ecology and behaviour of their hosts. However, questions remain pertaining to how host genetics shape microbiomes, and how microbiome composition influences host fitness. We explored the effects of geography, evolutionary history and host genetics on the skin microbiome diversity and structure in a widespread amphibian. More specifically, we examined the association between bacterial diversity and composition and the major histocompatibility complex class II exon 2 diversity in 12 moor frog (Rana arvalis) populations belonging to two geographical clusters that show signatures of past and ongoing differential selection. We found that while bacterial alpha diversity did not differ between the two clusters, MHC alleles/supertypes and genetic diversity varied considerably depending on geography and evolutionary history. Bacterial alpha diversity was positively correlated with expected MHC heterozygosity and negatively with MHC nucleotide diversity. Furthermore, bacterial community composition showed significant variation between the two geographical clusters and between specific MHC alleles/supertypes. Our findings emphasize the importance of historical demographic events on hologenomic variation and provide new insights into how immunogenetic host variability and microbial diversity may jointly influence host fitness with consequences for disease susceptibility and population persistence.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Kungliga Vetenskapsakademin
ID : BS2018-0110
Organisme : Stiftelsen Lars Hiertas Minne
ID : FO2018-0540
Organisme : Stiftelsen Oscar och Lili Lamms Minne
ID : DO2013-0013
Organisme : Stilftensen for zoologiska forskning
Organisme : Svenska Forskningsrådet Formas
ID : 146400178
Organisme : Swedish research Council
ID : 621-2013-4503
Informations de copyright
© 2023 The Authors. Molecular Ecology published by John Wiley & Sons Ltd.
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