Cell-Selective Binding Zwitterionic Polymeric Micelles Boost the Delivery Efficiency of Antibiotics.

Micelles Anti-Bacterial Agents / pharmacology Drug Delivery Systems Polymers / pharmacology Biofilms
Gram-positive bacteria RBC hitchhiking antibiotic delivery system biofilm penetration cell-wall affinity tertiary amine oxide

Journal

ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589

Informations de publication

Date de publication:
28 11 2023
Historique:
medline: 29 11 2023
pubmed: 7 11 2023
entrez: 7 11 2023
Statut: ppublish

Résumé

Effective accumulation and penetration of antibiotics in the biofilm are critical issues for bacterial infection treatment. Red blood cells (RBCs) have been widely utilized to hitchhike nanocarriers for drug delivery. It is vital and challenging to find a nanocarrier with an appropriate affinity toward RBCs and bacteria for selective hitchhiking and release that determines the drug delivery efficiency and specificity. Herein, we report a zwitterionic polymer poly(2-(

Identifiants

DOI: 10.1021/acsnano.3c05181 PMID: 37933869
pubmed: 37933869
doi: 10.1021/acsnano.3c05181
doi:

Substances chimiques

Micelles 0
Anti-Bacterial Agents 0
Polymers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

22430-22443

Auteurs

Huahai Yu (H)

Zhejiang Key Laboratory of Smart Biomaterials and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

Ying Piao (Y)

Zhejiang Key Laboratory of Smart Biomaterials and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

Yifan Zhang (Y)

Zhejiang Key Laboratory of Smart Biomaterials and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

Jiajia Xiang (J)

Zhejiang Key Laboratory of Smart Biomaterials and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

Shiqun Shao (S)

Zhejiang Key Laboratory of Smart Biomaterials and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
ORCID: 0000-0001-7029-3791

Jianbin Tang (J)

Zhejiang Key Laboratory of Smart Biomaterials and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
ORCID: 0000-0003-4498-5705

Zhuxian Zhou (Z)

Zhejiang Key Laboratory of Smart Biomaterials and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
ORCID: 0000-0002-7104-9915

Youqing Shen (Y)

Zhejiang Key Laboratory of Smart Biomaterials and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

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Classifications MeSH

questionsmedicales.fr › Préparations pharmaceutiques › Micelles › Cell-Selective Binding Zwitterionic Polymeric...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Cell-Selective Binding Zwitterionic Polymeric...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Cell-Selective Binding Zwitterionic Polymeric...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Cell-Selective Binding Zwitterionic Polymeric...
questionsmedicales.fr › Phénomènes microbiologiques › Biofilms › Cell-Selective Binding Zwitterionic Polymeric...