A prospective study to evaluate whether serum kisspeptin is a marker predictive of the first-trimester miscarriage of women who conceive in IVF.

Frozen-thawed embryo transfer IVF Kisspeptin Miscarriage

Journal

Journal of assisted reproduction and genetics

ISSN: 1573-7330

Titre abrégé: J Assist Reprod Genet

Pays: Netherlands

ID NLM: 9206495

Informations de publication

Date de publication:
08 Nov 2023

Historique:

received: 07 08 2023

accepted: 13 10 2023

medline: 8 11 2023

pubmed: 8 11 2023

entrez: 7 11 2023

Statut: aheadofprint

Résumé

Kisspeptin is an emerging biomarker for the discrimination of viable pregnancy. The aim of the study is to determine whether serum kisspeptin can predict the first-trimester miscarriage and compare it with serum HCG in the prediction of the first-trimester miscarriage. This study is a prospective case-control design including 178 women who had experienced early miscarriage (n = 21) and viable single pregnancy (n = 157), following frozen-thawed embryo transfer (FET) from May to December 2019. Serum samples on 14 days, 21 days, and 28 days after FET were collected for kisspeptin and HCG detection. NCT03940495. On day 21 after FET, serum kisspeptin levels were significantly lower in the early miscarriage group [0.260 (0.185-0.375)] vs in the viable single-pregnancy group [0.370 (0.280-0.495)] (p = 0.005). Similar results were shown on day 28 after FET, the serum kisspeptin levels were significantly lower in the early miscarriage group [0.270 (0.200-0.330)] vs in the viable single pregnancy group [0.670 (0.455-1.235)] (p < 0.001). But on day 14 after FET, serum kisspeptin levels were comparable in the early miscarriage group [0.260 (0.210-0.325)] and in the viable single-pregnancy group [0.280 (0.215-0.340)] (p = 0.551). Serum kisspeptin levels on days 21 and 28 have a poor predictive value of miscarriage compared with serum HCG levels. [Day 21: AUC = 0.687 (kisspeptin) and 0.816 (HCG); Day 28: AUC = 0.896 (kisspeptin) and 0.909 (HCG)]. Serum kisspeptin on day 14 failed to discriminate between miscarriage and ongoing pregnancies, and days 21 and 28 had poor predictive values of miscarriage.

Identifiants

DOI: 10.1007/s10815-023-02974-x PMID: 37935913

pubmed: 37935913

doi: 10.1007/s10815-023-02974-x

pii: 10.1007/s10815-023-02974-x

doi:

Banques de données

ClinicalTrials.gov

['NCT03940495']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Subventions

Organisme : Shanghai Municipal Health Commission

ID : 20194Y0036

Informations de copyright

Références

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