Relationship of Morphometrics and Symptom Severity in Female Type I Chiari Malformation Patients with Biological Resilience.
Allostatic load
And disability
Biomarkers
Chiari malformation Type I
Loneliness
Morphometrics
Journal
Cerebellum (London, England)
ISSN: 1473-4230
Titre abrégé: Cerebellum
Pays: United States
ID NLM: 101089443
Informations de publication
Date de publication:
07 Nov 2023
07 Nov 2023
Historique:
accepted:
25
10
2023
medline:
8
11
2023
pubmed:
8
11
2023
entrez:
7
11
2023
Statut:
aheadofprint
Résumé
In the present study we report the relationship among MRI-based skull and cervical spine morphometric measures as well as symptom severity (disability-as measured by Oswestry Head and Neck Pain Scale and social isolation-as measured by the UCLA Loneliness scale) on biomarkers of allostatic load using estrogen, interleukin-6, C-reactive protein, and cortisol in a sample of 46 CMI patients. Correlational analyses showed that McRae line length was negatively associated with interleukin-6 and C-reactive protein levels, and Analysis of Variance (ANOVA) showed joint effects of morphometric measures (McRae line length, anterior CSF space) and symptom severity (disability and loneliness) on estrogen and intereukin-6 levels. These results are consistent with allostatic load. That is, when the combination of CSF crowding and self-report symptom (disability and loneliness) severity exceed the capacity of biological resilience factors, then biomarkers such as neuroprotective estrogen levels drop, rather than rise, with increasing symptom severity.
Identifiants
pubmed: 37935987
doi: 10.1007/s12311-023-01627-0
pii: 10.1007/s12311-023-01627-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS and Conquer Chiari
ID : NINDS R15 Grant No. 1R15NS109957-01A1
Organisme : NINDS and Conquer Chiari
ID : NINDS R15 Grant No. 1R15NS109957-01A1
Organisme : NINDS and Conquer Chiari
ID : NINDS R15 Grant No. 1R15NS109957-01A1
Organisme : NINDS and Conquer Chiari
ID : NINDS R15 Grant No. 1R15NS109957-01A1
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Milhorat TH, et al. Chiari I malformation redefined: clinical and radiographic findings for 364 symptomatic patients. Neurosurgery. 1999;44(5):1005–17. https://doi.org/10.1097/00006123-199905000-00042 .
doi: 10.1097/00006123-199905000-00042
pubmed: 10232534
Houston JR, et al. A morphometric assessment of type I Chiari malformation above the McRae line: A retrospective case-control study in 302 adult female subjects. J Neuroradiol. 2018;45(1):23–31. https://doi.org/10.1016/j.neurad.2017.06.006 .
doi: 10.1016/j.neurad.2017.06.006
pubmed: 28826656
Eppelheimer MS, et al. Quantification of changes in brain morphology following posterior fossa decompression surgery in women treated for Chiari malformation type 1. Neuroradiology. 2019;61(9):1011–22. https://doi.org/10.1007/s00234-019-02206-z .
doi: 10.1007/s00234-019-02206-z
pubmed: 31119343
Fischbein R, et al. Patient-reported Chiari malformation type I symptoms and diagnostic experiences: a report from the national conquer chiari patient registry database. Neurol Sci. 2015;36(9):1617–24. https://doi.org/10.1007/s10072-015-2219-9 .
doi: 10.1007/s10072-015-2219-9
pubmed: 25972139
Allen PA, et al. Task-specific and general cognitive effects in Chiari malformation type I. PLoS One. 2014;9(4):e94844. https://doi.org/10.1371/journal.pone.0094844 .
doi: 10.1371/journal.pone.0094844
pubmed: 24736676
pmcid: 3988081
Houston JR, et al. Type I Chiari malformation, RBANS performance, and brain morphology: Connecting the dots on cognition and macrolevel brain structure. Neuropsychology. 2019;33(5):725–38. https://doi.org/10.1037/neu0000547 .
doi: 10.1037/neu0000547
pubmed: 31094552
Rogers JM, Savage G, Stoodley MA. A systematic review of cognition in Chiari I malformation. Neuropsychol Rev. 2018;28(2):176–87. https://doi.org/10.1007/s11065-018-9368-6 .
doi: 10.1007/s11065-018-9368-6
pubmed: 29468516
Garcia M, et al. Comparison between decompressed and non-decompressed Chiari malformation type I patients: a neuropsychological study. Neuropsychologia. 2018;121:135–43. https://doi.org/10.1016/j.neuropsychologia.2018.11.002 .
doi: 10.1016/j.neuropsychologia.2018.11.002
pubmed: 30412712
Houston ML, Houston JR, Sakaie K, Klinge PM, Vorster S, Luciano MG, Loth F, Allen PA. Functional connectivity abnormalities in Type I Chiari: associations with cognition and pain. Brain Commun. 2021. https://doi.org/10.1093/braincomms/fcab137 .
Garcia MA, et al. An examination of pain, disability, and the psychological correlates of Chiari Malformation pre- and post-surgical correction. Disabil Health J. 2019;12(4):649–56. https://doi.org/10.1016/j.dhjo.2019.05.004 .
doi: 10.1016/j.dhjo.2019.05.004
pubmed: 31147250
Yilmaz A, et al. When is duraplasty required in the surgical treatment of Chiari malformation type I based on tonsillar descending grading scale? World Neurosurg. 2011;75(2):307–13. https://doi.org/10.1016/j.wneu.2010.09.005 .
doi: 10.1016/j.wneu.2010.09.005
pubmed: 21492735
Eppelheimer MS, et al. Cerebellar and brainstem displacement measured with DENSE MRI in Chiari malformation following posterior fossa decompression surgery. Radiology. 2021;301(1):187–94. https://doi.org/10.1148/radiol.2021203036 .
doi: 10.1148/radiol.2021203036
pubmed: 34313469
Biswas D, et al. Quantification of cerebellar crowding in type I Chiari malformation. Ann Biomed Eng. 2019;47(3):731–43. https://doi.org/10.1007/s10439-018-02175-z .
doi: 10.1007/s10439-018-02175-z
pubmed: 30535814
Cremeans-Smith JK, Boarts JM, Greene K, Delahanty DL. Patients’ reasons for electing to undergo total knee arthroplasty impact post-operative pain severity and range of motion. J Behav Med. 2009;32(3):223–33. https://doi.org/10.1007/s10865-008-9191-2 .
doi: 10.1007/s10865-008-9191-2
pubmed: 19137422
Garcia MA, Li X, Allen PA, Delahanty DL, Eppelheimer MS, Houston JR, Johnson DM, Loth F, Maleki J, Vorster S, Luciano MG. Impact of surgical status, loneliness, and disability on interleukin 6, C-reactive protein, cortisol, and estrogen in females with symptomatic type I Chiari malformation. Cerebellum. 2021. https://doi.org/10.1007/s12311-021-01251-w .
García M, Eppelheimer MS, Houston JR, Hughes ML, Nwotchouang BST, Kaut KP, Labuda R, Bapuraj JR, Maleki J, Klinge PM, Vorster S, Luciano MG, Loth F, Allen PA. Adult age differences in self-reported pain and anterior CSF space in Chiari malformation. Cerebellum. 2022;21(2):194–207. https://doi.org/10.1007/s12311-021-01289-w .
McEwen BS, Alves SE. Estrogen actions in the central nervous system. Endocr Rev. 1999;20(3):279–307. https://doi.org/10.1210/edrv.20.3.0365 .
doi: 10.1210/edrv.20.3.0365
pubmed: 10368772
McEwen BS, Stellar E. Stress and the individual. Mechanisms leading to disease. Arch Intern Med. 1993;153(18):2093–101. [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/8379800 .
Juster RP, McEwen BS, Lupien SJ. Allostatic load biomarkers of chronic stress and impact on health and cognition. Neurosci Biobehav Rev. 2010;35(1):2–16. https://doi.org/10.1016/j.neubiorev.2009.10.002 .
doi: 10.1016/j.neubiorev.2009.10.002
pubmed: 19822172
Russell D. UCLA loneliness scale (Version 3): reliability, validity, and factor structure. J Pers Assess. 1996;66:20–40.
doi: 10.1207/s15327752jpa6601_2
pubmed: 8576833
Fairbanks CT, Couper C, Davies JB, O’Brien JP. The Oswestry low backpain disability questionannaire. Physiotherapy. 1980;66:271–3.
Hoche F, Guell X, Vangel MG, Sherman JC, Schmahmann JD. The cerebellar cognitive affective/Schmahmann syndrome scale. Brain. 2018;141(1):248–70. https://doi.org/10.1093/brain/awx317 .
doi: 10.1093/brain/awx317
pubmed: 29206893
Van Overwalle F, Manto M, Leggio M, Delgado-Garcia JM. The sequencing process generated by the cerebellum crucially contributes to social interactions. Med Hypotheses. 2019;128:33–42. https://doi.org/10.1016/j.mehy.2019.05.014 .
doi: 10.1016/j.mehy.2019.05.014
pubmed: 31203906
García M, Amayra I, López-Paz JF, Martínez O, Lázaro E, Pérez M, Berrocoso S, Al-Rashaida M, Infante J. Social cognition in Chiari malformation type I: a preliminary characterization. Cerebellum. 2020;19:392–400. https://doi.org/10.1007/s12311-020-01117-7 .
doi: 10.1007/s12311-020-01117-7
pubmed: 32048182
Allen PA, et al. Chiari 1000 registry project: assessment of surgical outcome on self-focused attention, pain, and delayed recall. Psychol Med. 2018;48(10):1634–43. https://doi.org/10.1017/S0033291717003117 .
doi: 10.1017/S0033291717003117
pubmed: 29048273
Lovibond PF, Lovibond SH. The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the beck depression and anxiety inventories. Behav Res Ther. 1995;33(3):335–43. https://doi.org/10.1016/0005-7967(94)00075-u .
doi: 10.1016/0005-7967(94)00075-u
pubmed: 7726811
Dworkin RH, et al. Development and initial validation of an expanded and revised version of the Short-form McGill Pain Questionnaire (SF-MPQ-2). Pain. 2009;144(1–2):35–42. https://doi.org/10.1016/j.pain.2009.02.007 .
doi: 10.1016/j.pain.2009.02.007
pubmed: 19356853
Fairbank JCT, Pynsent PB. The oswestry disability index. Spine. 2000;25(22):2940–52. https://doi.org/10.1097/00007632-200011150-00017 (in English).
doi: 10.1097/00007632-200011150-00017
pubmed: 11074683
Vernon H, Mior S. The neck disability index - a study of reliability and validity. J Manip Physiol Ther. 1991;14(7):409–415. [Online]. Available: <Go to ISI>://WOS:A1991GF68000002 (in English).
Keppel G. Design and Analysis: A researcher’s handbook. Englewood Cliffs, N.J.: Prentice-Hall; 1982.