Insights into the structure and function of the RNA ligase RtcB.
3′–5′ RNA ligase
Archease
Cancer
Crystal structure
RNA 2′,3′-cyclic phosphate and 5′-OH ligase [RtcB]
RNA ligation
Transfer RNA [tRNA]
Unfolded protein response [UPR]
X-box-binding protein 1 [XBP1]
tRNA ligase complex
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
07 Nov 2023
07 Nov 2023
Historique:
received:
10
08
2023
accepted:
11
10
2023
revised:
19
09
2023
medline:
9
11
2023
pubmed:
8
11
2023
entrez:
7
11
2023
Statut:
epublish
Résumé
To be functional, some RNAs require a processing step involving splicing events. Each splicing event necessitates an RNA ligation step. RNA ligation is a process that can be achieved with various intermediaries such as self-catalysing RNAs, 5'-3' and 3'-5' RNA ligases. While several types of RNA ligation mechanisms occur in human, RtcB is the only 3'-5' RNA ligase identified in human cells to date. RtcB RNA ligation activity is well known to be essential for the splicing of XBP1, an essential transcription factor of the unfolded protein response; as well as for the maturation of specific intron-containing tRNAs. As such, RtcB is a core factor in protein synthesis and homeostasis. Taking advantage of the high homology between RtcB orthologues in archaea, bacteria and eukaryotes, this review will provide an introduction to the structure of RtcB and the mechanism of 3'-5' RNA ligation. This analysis is followed by a description of the mechanisms regulating RtcB activity and localisation, its known partners and its various functions from bacteria to human with a specific focus on human cancer.
Identifiants
pubmed: 37935993
doi: 10.1007/s00018-023-05001-5
pii: 10.1007/s00018-023-05001-5
pmc: PMC10630183
doi:
Substances chimiques
RNA Ligase (ATP)
EC 6.5.1.3
Transcription Factors
0
RNA
63231-63-0
RNA, Transfer
9014-25-9
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
352Subventions
Organisme : Science Foundation Ireland
ID : 13/RC/2073
Pays : Ireland
Organisme : Science Foundation Ireland
ID : 13/RC/2073
Pays : Ireland
Informations de copyright
© 2023. The Author(s).
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