Subvalvular Aortic Stenosis: Learning From Human and Canine Clinical Research.
Animal model
Aortic valve
Congenital heart disease
Discrete subaortic stenosis
Fixed subaortic stenosis
Left ventricular outflow tract
Translational approach
Journal
Cardiology research
ISSN: 1923-2829
Titre abrégé: Cardiol Res
Pays: Canada
ID NLM: 101557543
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
12
07
2023
accepted:
03
10
2023
medline:
8
11
2023
pubmed:
8
11
2023
entrez:
8
11
2023
Statut:
ppublish
Résumé
Subvalvular aortic stenosis (SAS) is the most common congenital heart disease (CHD) in dogs and is also prevalent in human children. A fibrous ridge below the aortic valve narrows the left ventricular outflow tract (LVOT) and increases blood flow velocity, leading to devastating side effects in diseased patients. Due to the similarities in presentation, anatomy, pathophysiology, cardiac development, genomics, and environment between humans and dogs, canine SAS patients represent a critical translational model of human SAS. Potential adverse outcomes of SAS include arrhythmias, left-sided congestive heart failure, endocarditis, exercise intolerance, syncope, and sudden cardiac death. The greatest divergence between canine and human SAS clinical research has been the standard of care regarding treatment of these outcomes, with pharmacological intervention dominating best practices in veterinary medicine and surgical intervention comprising the standard practice for human SAS patients. Regardless of the species, the field has yet to identify a treatment option to prevent disease progression or permanently remove the fibrous ridge, but historical leaps in SAS research support a continued translational approach as the most promising method for achieving this goal.
Identifiants
pubmed: 37936623
doi: 10.14740/cr1547
pmc: PMC10627371
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
319-333Informations de copyright
Copyright 2023, Crofton et al.
Déclaration de conflit d'intérêts
None to declare.
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