Early-life microbiota-immune homeostasis.

dysbiosis early-life fecal microbiota transplant gut microbiota immune homeostasis prebiotics probiotics

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2023
Historique:
received: 25 07 2023
accepted: 11 10 2023
medline: 9 11 2023
pubmed: 8 11 2023
entrez: 8 11 2023
Statut: epublish

Résumé

As the prevalence of allergy and autoimmune disease in industrialized societies continues to rise, improving our understanding of the mechanistic roles behind microbiota-immune homeostasis has become critical for informing therapeutic interventions in cases of dysbiosis. Of particular importance, are alterations to intestinal microbiota occurring within the critical neonatal window, during which the immune system is highly vulnerable to environmental exposures. This review will highlight recent literature concerning mechanisms of early-life microbiota-immune homeostasis as well as discuss the potential for therapeutics in restoring dysbiosis in early life.

Identifiants

pubmed: 37936686
doi: 10.3389/fimmu.2023.1266876
pmc: PMC10627000
doi:

Types de publication

Journal Article Review Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1266876

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI136963
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI173406
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI138945
Pays : United States

Informations de copyright

Copyright © 2023 Reynolds and Bettini.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

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Auteurs

Hayley M Reynolds (HM)

Department of Microbiology and Immunology, University of Utah, Salt Lake, UT, United States.

Matthew L Bettini (ML)

Department of Microbiology and Immunology, University of Utah, Salt Lake, UT, United States.

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