Toll-Like Receptor (
TLR1
TLR2
TLR6
gene–gene interaction
immune response
schizophrenia
Journal
Neuropsychiatric disease and treatment
ISSN: 1176-6328
Titre abrégé: Neuropsychiatr Dis Treat
Pays: New Zealand
ID NLM: 101240304
Informations de publication
Date de publication:
2023
2023
Historique:
received:
30
05
2023
accepted:
14
09
2023
medline:
8
11
2023
pubmed:
8
11
2023
entrez:
8
11
2023
Statut:
epublish
Résumé
Schizophrenia is a complex psychiatric disorder with an important genetic contribution. Immunological abnormalities have been reported in schizophrenia. Toll-like receptor (TLR) genes play an important role in the activation of the innate immune response, which may help to explain the presence of inflammation in people with this disorder. The aim of this study was to analyze the association of We included 582 patients with schizophrenia and 525 healthy controls. Genetic analysis was performed using allelic discrimination with TaqMan probes. We observed significant differences between patients and controls in the genotype and allele frequencies of Our findings add to the evidence suggesting that the activation of innate immune response might play an important role in the development of schizophrenia.
Identifiants
pubmed: 37936867
doi: 10.2147/NDT.S420952
pii: 420952
pmc: PMC10627067
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2353-2361Informations de copyright
© 2023 Sotelo-Ramírez et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
Psychopharmacol Bull. 2007;40(4):178-90
pubmed: 18227787
Psychol Med. 2017 Oct;47(13):2229-2237
pubmed: 28418288
Psychiatry Res. 2019 Feb;272:540-550
pubmed: 30616121
Lancet Psychiatry. 2015 Mar;2(3):258-270
pubmed: 26359903
PLoS One. 2015 Mar 17;10(3):e0116696
pubmed: 25781172
Neurosci Biobehav Rev. 2014 Jan;38:72-93
pubmed: 24247023
Schizophr Bull. 2018 Oct 17;44(6):1195-1203
pubmed: 29762765
Am J Psychiatry. 2011 Dec;168(12):1303-10
pubmed: 22193673
Curr Pharm Des. 2016;22(40):6122-6133
pubmed: 27604609
Genet Epidemiol. 2003 Feb;24(2):150-7
pubmed: 12548676
JAMA Psychiatry. 2020 Feb 1;77(2):201-210
pubmed: 31664453
Lancet. 2016 Jul 2;388(10039):86-97
pubmed: 26777917
Genetics. 2016 Dec;204(4):1587-1600
pubmed: 27754856
Schizophr Bull. 2018 Jan 13;44(1):75-83
pubmed: 28338954
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 1;44:301-11
pubmed: 23587629
J Psychiatry Neurosci. 2016 Apr;41(3):E46-55
pubmed: 27070349
Psychol Med. 1991 Aug;21(3):565-75
pubmed: 1946845
Schizophr Res. 2010 Sep;122(1-3):38-42
pubmed: 20659789
Nature. 2014 Jul 24;511(7510):421-7
pubmed: 25056061
Cell. 2015 Mar 12;160(6):1111-24
pubmed: 25768907
Cell J. 2021 Jan;22(4):572-574
pubmed: 32347052
J Biomed Sci. 2019 Nov 4;26(1):90
pubmed: 31684953
Bioinformatics. 2007 Apr 15;23(8):1038-9
pubmed: 17308338
Nat Rev Dis Primers. 2015 Nov 12;1:15067
pubmed: 27189524
Genome Res. 2002 Jun;12(6):996-1006
pubmed: 12045153
Neurosci Biobehav Rev. 2012 Jan;36(1):556-71
pubmed: 21946175
Bioinformatics. 2005 Jan 15;21(2):263-5
pubmed: 15297300
Cell. 2004 Jul 23;118(2):229-41
pubmed: 15260992
Bioinformatics. 2003 Feb 12;19(3):376-82
pubmed: 12584123
Nature. 2009 Aug 6;460(7256):748-52
pubmed: 19571811
Nat Genet. 2012 Feb 19;44(3):247-50
pubmed: 22344220
Sci Rep. 2017 Jun 23;7(1):4147
pubmed: 28646138
JAMA Psychiatry. 2019 Jun 1;76(6):594-602
pubmed: 30840048
PLoS One. 2020 Feb 13;15(2):e0228730
pubmed: 32053646
J Immunol. 2004 Oct 1;173(7):4286-96
pubmed: 15383557
J Psychiatr Res. 2019 Jul;114:178-207
pubmed: 31096178
PLoS One. 2015 Mar 19;10(3):e0119702
pubmed: 25790282