Micro-porous PLGA/
mesenchymal stromal cells
osteogenesis
porosity
regenerative scaffold
solvent-based printing
Journal
Regenerative biomaterials
ISSN: 2056-3418
Titre abrégé: Regen Biomater
Pays: England
ID NLM: 101652150
Informations de publication
Date de publication:
2023
2023
Historique:
received:
22
05
2023
revised:
14
08
2023
accepted:
31
08
2023
medline:
8
11
2023
pubmed:
8
11
2023
entrez:
8
11
2023
Statut:
epublish
Résumé
The 3D printing process of fused deposition modelling is an attractive fabrication approach to create tissue-engineered bone substitutes to regenerate large mandibular bone defects, but often lacks desired surface porosity for enhanced protein adsorption and cell adhesion. Solvent-based printing leads to the spontaneous formation of micropores on the scaffold's surface upon solvent removal, without the need for further post processing. Our aim is to create and characterize porous scaffolds using a new formulation composed of mechanically stable poly(lactic-co-glycol acid) and osteoconductive β-tricalcium phosphate with and without the addition of elastic thermoplastic polyurethane prepared by solvent-based 3D-printing technique. Large-scale regenerative scaffolds can be 3D-printed with adequate fidelity and show porosity at multiple levels analysed via micro-computer tomography, scanning electron microscopy and N
Identifiants
pubmed: 37936893
doi: 10.1093/rb/rbad084
pii: rbad084
pmc: PMC10627288
doi:
Types de publication
Journal Article
Langues
eng
Pagination
rbad084Informations de copyright
© The Author(s) 2023. Published by Oxford University Press.
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