Direct wire pacing during measurement of fractional flow reserve: A randomized proof-of-concept noninferiority crossover trial.
FFR = fractional flow reserve
adenosine
cardiac pacing
direct wire pacing
innovation
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2023
2023
Historique:
received:
04
01
2023
accepted:
30
03
2023
medline:
8
11
2023
pubmed:
8
11
2023
entrez:
8
11
2023
Statut:
epublish
Résumé
Adenosine administration for fractional flow reserve (FFR) measurement may induce heart pauses. To assess the accuracy and tolerability of direct wire pacing (DWP) during measurement of FFR. Adults with at least one intermediate coronary artery stenosis (40%-80%) were consecutively enrolled between June 2021 and February 2022 in this randomized, noninferiority, crossover trial (NCT04970082) carried out in France. DWP was applied (DWP) or not (standard method) through the pressure guidewire used for FFR measurement during adenosine-induced maximal hyperaemia. Subjects were randomly assigned to the allocation sequence (DWP first or standard first). A 2-minute washout period was observed between the two FFR measurements performed for each stenosis. The primary endpoint was the reproducibility of FFR measurements between methods. A total of 150 focal lesions, presented by 94 subjects, were randomized (ratio: 1:1). The FFR values obtained with each method were nearly identical ( DWP during FFR measurement resulted in accurate and reproducible FFR values, and eliminated the pauses induced by adenosine.
Sections du résumé
Background
UNASSIGNED
Adenosine administration for fractional flow reserve (FFR) measurement may induce heart pauses.
Aims
UNASSIGNED
To assess the accuracy and tolerability of direct wire pacing (DWP) during measurement of FFR.
Methods
UNASSIGNED
Adults with at least one intermediate coronary artery stenosis (40%-80%) were consecutively enrolled between June 2021 and February 2022 in this randomized, noninferiority, crossover trial (NCT04970082) carried out in France. DWP was applied (DWP) or not (standard method) through the pressure guidewire used for FFR measurement during adenosine-induced maximal hyperaemia. Subjects were randomly assigned to the allocation sequence (DWP first or standard first). A 2-minute washout period was observed between the two FFR measurements performed for each stenosis. The primary endpoint was the reproducibility of FFR measurements between methods.
Results
UNASSIGNED
A total of 150 focal lesions, presented by 94 subjects, were randomized (ratio: 1:1). The FFR values obtained with each method were nearly identical (
Conclusions
UNASSIGNED
DWP during FFR measurement resulted in accurate and reproducible FFR values, and eliminated the pauses induced by adenosine.
Identifiants
pubmed: 37937287
doi: 10.3389/fcvm.2023.1137309
pmc: PMC10625906
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1137309Informations de copyright
© 2023 Faurie, Acheampong, Abdellaoui, Dessus, Monsegu and Wintzer-Wehekind.
Déclaration de conflit d'intérêts
Sponsorship of this study was provided by the "Centre de Recherche Cardiovasculaire des Alpes (CRCA)”, Grenoble, France. BF and JM work at the CRCA and have received honoraria as speakers for OpSens Medical. MA also works at the CRCA. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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