KLF4 suppresses the proliferation of perihilar cholangiocarcinoma by negatively regulating GDF15 and phosphorylating AKT.
Krüppel‑like factor 4
growth/differentiation factor 15
perihilar cholangiocarcinoma
prognosis
proliferation
Journal
Oncology reports
ISSN: 1791-2431
Titre abrégé: Oncol Rep
Pays: Greece
ID NLM: 9422756
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
30
10
2022
accepted:
07
06
2023
medline:
9
11
2023
pubmed:
8
11
2023
entrez:
8
11
2023
Statut:
ppublish
Résumé
Krüppel‑like factor 4 (KLF4) is a transcription factor which functions as a tumor suppressor or an oncogene in numerous types of solid tumors. However, its expression levels and function in perihilar cholangiocarcinoma (pCCA) have yet to be elucidated. In the present study, in order to investigate its roles in pCCA, reverse transcription‑quantitative PCR (RT‑qPCR), western blot analysis and immunohistochemistry were used to detect KLF4 expression in pCCA. The Chi‑squared test was used to analyze the associations between KLF4 and the clinicopathological features of patients with pCCA. Univariate and multivariate analyses were subsequently used to analyze the prognostic significance of KLF4. The tumor suppression of KLF4 was investigated for the purposes of illustrating its biological function both
Identifiants
pubmed: 37937607
doi: 10.3892/or.2023.8659
pii: 222
pmc: PMC10652240
doi:
pii:
Substances chimiques
GDF15 protein, human
0
Growth Differentiation Factor 15
0
Kruppel-Like Factor 4
0
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
KLF4 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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