L-Palmitoylcarnitine potentiates plasmin and tPA to inhibit thrombosis.
Coagulation
L-palmitoylcarnitine
Plasmin
Thrombosis
Tissue-type plasminogen activator
Journal
Natural products and bioprospecting
ISSN: 2192-2195
Titre abrégé: Nat Prod Bioprospect
Pays: Germany
ID NLM: 101577734
Informations de publication
Date de publication:
08 Nov 2023
08 Nov 2023
Historique:
received:
18
09
2023
accepted:
25
10
2023
medline:
8
11
2023
pubmed:
8
11
2023
entrez:
8
11
2023
Statut:
epublish
Résumé
L-Palmitoylcarnitine (L-PC) is an important endogenous fatty acid metabolite. Its classical biological functions are involved in the regulations of membrane molecular dynamics and the β-oxidation of fatty acids. Decreased plasma long-chain acylcarnitines showed the association of venous thrombosis, implying anticoagulant activity of the metabolites and inspiring us to investigate if and how L-PC, a long-chain acylcarnitine, takes part in coagulation. Here we show that L-PC exerted anti-coagulant effects by potentiating the enzymatic activities of plasmin and tissue plasminogen activator (tPA). L-PC directly interacts with plasmin and tPA with an equilibrium dissociation constant (KD) of 6.47 × 10
Identifiants
pubmed: 37938456
doi: 10.1007/s13659-023-00413-z
pii: 10.1007/s13659-023-00413-z
pmc: PMC10632336
doi:
Types de publication
Journal Article
Langues
eng
Pagination
48Subventions
Organisme : Priority Union Foundation of Yunnan Provincial Science and Technology Department and Kunming Medical University
ID : 202101AC070461
Informations de copyright
© 2023. The Author(s).
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