A novel LC-MS/MS method to characterize the antimicrobial lipid glycerol monolaurate in global human milk.
Human milk
Isomerization
LC-MS/MS
Laurates
Monoglycerides
Journal
Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336
Informations de publication
Date de publication:
20 Jan 2024
20 Jan 2024
Historique:
received:
11
08
2023
revised:
16
10
2023
accepted:
25
10
2023
medline:
6
12
2023
pubmed:
9
11
2023
entrez:
8
11
2023
Statut:
ppublish
Résumé
Glycerol monolaurate (GML), a monoglyceride found in human milk (HM), has antimicrobial properties against a broad spectrum of bacteria, viruses, and fungi. In this study, an LC-MS/MS method was developed and validated for quantifying GML in HM based on quantification of two distinct isomers, 1-monolaurin and 2-monolaurin. The method validation included assessments of selectivity (no interferences), linearity (r
Identifiants
pubmed: 37939550
pii: S0731-7085(23)00586-1
doi: 10.1016/j.jpba.2023.115817
pii:
doi:
Substances chimiques
monolaurin
27215-38-9
Monoglycerides
0
Anti-Infective Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115817Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest TV, NAM, SDM, LB, RS, MAG, and SCP are all employees of Reckitt/Mead Johnson Nutrition, NS was previously employed by Reckitt/Mead John Nutrition and ALM received funding from Reckitt/Mead Johnson Nutrition for the GEHM study.