Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty.

Chronic toxoplasmosis Inflammaging Kynurenine to tryptophan ratio sTNF-RII

Journal

The journals of gerontology. Series A, Biological sciences and medical sciences
ISSN: 1758-535X
Titre abrégé: J Gerontol A Biol Sci Med Sci
Pays: United States
ID NLM: 9502837

Informations de publication

Date de publication:
06 Nov 2023
Historique:
received: 01 11 2022
medline: 9 11 2023
pubmed: 9 11 2023
entrez: 8 11 2023
Statut: aheadofprint

Résumé

Persistent inflammation related to aging ("inflammaging") is exacerbated by chronic infections and contributes to frailty in older adults. We hypothesized associations between Toxoplasma gondii (T. gondii), a common parasite causing an oligosymptomatic unremitting infection, and frailty, and secondarily between T. gondii and previously reported markers of immune activation in frailty. We analyzed available demographic, social, and clinical data in Spanish and Portuguese older adults [N = 601; age: mean (SD) 77.3 (8.0); 61% women]. Plasma T. gondii immunoglobulin G (IgG) serointensity was measured with an enzyme-linked immunosorbent assay. The Fried criteria were used to define frailty status. Validated translations of Mini-Mental State Examination, Geriatric Depression Scale, and the Charlson Comorbidity Index were used to evaluate confounders. Previously analyzed biomarkers that were significantly associated with frailty in both prior reports and the current study, and also related to T. gondii serointensity, were further accounted for in multivariable logistic models with frailty as outcome. In T. gondii-seropositives, there was a significant positive association between T. gondii IgG serointensity and frailty, accounting for age (p = .0002), and resisting adjustment for multiple successive confounders. Among biomarkers linked with frailty, kynurenine/tryptophan and soluble tumor necrosis factor receptor II were positively associated with T. gondii serointensity in seropositives (p < .05). Associations with other biomarkers were not significant. This first reported association between T. gondii and frailty is limited by a cross-sectional design and warrants replication. While certain biomarkers of inflammaging were associated with both T. gondii IgG serointensity and frailty, they did not fully mediate the T. gondii-frailty association.

Sections du résumé

BACKGROUND BACKGROUND
Persistent inflammation related to aging ("inflammaging") is exacerbated by chronic infections and contributes to frailty in older adults. We hypothesized associations between Toxoplasma gondii (T. gondii), a common parasite causing an oligosymptomatic unremitting infection, and frailty, and secondarily between T. gondii and previously reported markers of immune activation in frailty.
METHODS METHODS
We analyzed available demographic, social, and clinical data in Spanish and Portuguese older adults [N = 601; age: mean (SD) 77.3 (8.0); 61% women]. Plasma T. gondii immunoglobulin G (IgG) serointensity was measured with an enzyme-linked immunosorbent assay. The Fried criteria were used to define frailty status. Validated translations of Mini-Mental State Examination, Geriatric Depression Scale, and the Charlson Comorbidity Index were used to evaluate confounders. Previously analyzed biomarkers that were significantly associated with frailty in both prior reports and the current study, and also related to T. gondii serointensity, were further accounted for in multivariable logistic models with frailty as outcome.
RESULTS RESULTS
In T. gondii-seropositives, there was a significant positive association between T. gondii IgG serointensity and frailty, accounting for age (p = .0002), and resisting adjustment for multiple successive confounders. Among biomarkers linked with frailty, kynurenine/tryptophan and soluble tumor necrosis factor receptor II were positively associated with T. gondii serointensity in seropositives (p < .05). Associations with other biomarkers were not significant.
CONCLUSIONS CONCLUSIONS
This first reported association between T. gondii and frailty is limited by a cross-sectional design and warrants replication. While certain biomarkers of inflammaging were associated with both T. gondii IgG serointensity and frailty, they did not fully mediate the T. gondii-frailty association.

Identifiants

DOI: 10.1093/gerona/glad228 PMID: 37939652
pubmed: 37939652
pii: 7334598
doi: 10.1093/gerona/glad228
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIA NIH HHS
ID : NIA R01 AG018859
Pays : United States
Organisme : NIH HHS
Pays : United States

Informations de copyright

© The Author(s) 2023. Published by Oxford University Press on behalf of The Gerontological Society of America.

Auteurs

Hira Mohyuddin (H)

Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Psychiatry Residency Training Program, George Washington University, Washington, District of Columbia, USA.

Blanca Laffon (B)

Universidade da Coruña, Grupo DICOMOSA, CICA-Centro Interdisciplinar de Química e Bioloxía, Departamento de Psicología, Facultad de Ciencias de la Educación, Campus Elviña s/n, A Coruña, Spain.
Instituto de Investigación Biomédica de A Coruña (INIBIC), Oza, A Coruña, Spain.
ORCID: 0000-0001-7649-2599

João P Teixeira (JP)

Environment Health Department, National Institute of Health Dr Ricardo Jorge, Porto, Portugal.
EPIUnit - Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal.

Solange Costa (S)

Environment Health Department, National Institute of Health Dr Ricardo Jorge, Porto, Portugal.
EPIUnit - Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal.

Armanda Teixeira-Gomes (A)

EPIUnit - Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal.
School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal.

Eduardo Pásaro (E)

Universidade da Coruña, Grupo DICOMOSA, CICA-Centro Interdisciplinar de Química e Bioloxía, Departamento de Psicología, Facultad de Ciencias de la Educación, Campus Elviña s/n, A Coruña, Spain.
Instituto de Investigación Biomédica de A Coruña (INIBIC), Oza, A Coruña, Spain.

Niel Constantine (N)

Institute of Human Virology and Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Aline Dagdag (A)

Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Heidi K Ortmeyer (HK)

Baltimore VA Medical Center, Baltimore, Maryland, USA.
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Boris Tizenberg (B)

Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Liubov Afram (L)

Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Poyu Yen (P)

Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Christopher Marano (C)

Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Christopher A Lowry (CA)

Department of Integrative Physiology, Department of Psychology and Neuroscience, Center for Neuroscience, and Center for Microbial Exploration, University of Colorado Boulder, Boulder, Colorado, USA.
VA Rocky Mountain Mental Illness Research Education and Clinical Center (MIRECC), Aurora, Colorado, USA.

Andrew J Hoisington (AJ)

VA Rocky Mountain Mental Illness Research Education and Clinical Center (MIRECC), Aurora, Colorado, USA.
Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Jill A RachBeisel (JA)

Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Vanessa Valdiglesias (V)

Instituto de Investigación Biomédica de A Coruña (INIBIC), Oza, A Coruña, Spain.
Universidade da Coruña, Grupo NanoToxGen, CICA-Centro Interdisciplinar de Química e Bioloxía, Departamento de Biología, Facultad de Ciencias, Campus A Zapateira s/n, A Coruña, Spain.
ORCID: 0000-0002-5572-1089

Carlota Lema-Arranz (C)

Universidade da Coruña, Grupo DICOMOSA, CICA-Centro Interdisciplinar de Química e Bioloxía, Departamento de Psicología, Facultad de Ciencias de la Educación, Campus Elviña s/n, A Coruña, Spain.
Instituto de Investigación Biomédica de A Coruña (INIBIC), Oza, A Coruña, Spain.

Natalia Fernández-Bertólez (N)

Instituto de Investigación Biomédica de A Coruña (INIBIC), Oza, A Coruña, Spain.
Universidade da Coruña, Grupo NanoToxGen, CICA-Centro Interdisciplinar de Química e Bioloxía, Departamento de Biología, Facultad de Ciencias, Campus A Zapateira s/n, A Coruña, Spain.

Ana Maseda (A)

Universidade da Coruña, Gerontology and Geriatrics Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Servizo Galego de Saúde (SERGAS), A Coruña, Spain.
ORCID: 0000-0002-6693-539X

José C Millán-Calenti (JC)

Universidade da Coruña, Gerontology and Geriatrics Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Servizo Galego de Saúde (SERGAS), A Coruña, Spain.

Elizabeth J Kovacs (EJ)

VA Rocky Mountain Mental Illness Research Education and Clinical Center (MIRECC), Aurora, Colorado, USA.
Department of Surgery, Division of GI, Trauma and Endocrine Surgery, Alcohol Research Program, Burn Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado USA.

Johanna M Gostner (JM)

Institute of Medical Biochemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria.

Dietmar Fuchs (D)

Institute of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria.
ORCID: 0000-0003-1627-9563

Lisa A Brenner (LA)

VA Rocky Mountain Mental Illness Research Education and Clinical Center (MIRECC), Aurora, Colorado, USA.
Departments of Psychiatry, Physical Medicine and Rehabilitation, and Neurology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Laura Lorenzo-López (L)

Universidade da Coruña, Gerontology and Geriatrics Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Servizo Galego de Saúde (SERGAS), A Coruña, Spain.
ORCID: 0000-0003-4870-6515

Teodor T Postolache (TT)

Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
VA Rocky Mountain Mental Illness Research Education and Clinical Center (MIRECC), Aurora, Colorado, USA.

Classifications MeSH