The mitochondrial signature of cultured endothelial cells in sepsis: Identifying potential targets for treatment.
Endothelium
Mitochondria
Organ dysfunction
Sepsis
Septic shock
Therapy
Journal
Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730
Informations de publication
Date de publication:
07 Nov 2023
07 Nov 2023
Historique:
received:
24
07
2023
revised:
23
10
2023
accepted:
30
10
2023
pubmed:
9
11
2023
medline:
9
11
2023
entrez:
8
11
2023
Statut:
aheadofprint
Résumé
Sepsis is the most common cause of death from infection in the world. Unfortunately, there is no specific treatment for patients with sepsis, and management relies on infection control and support of organ function. A better understanding of the underlying pathophysiology of this syndrome will help to develop innovative therapies. In this regard, it has been widely reported that endothelial cell activation and dysfunction are major contributors to the development of sepsis. This review aims to provide a comprehensive overview of emerging findings highlighting the prominent role of mitochondria in the endothelial response in in vitro experimental models of sepsis. Additionally, we discuss potential mitochondrial targets that have demonstrated protective effects in preclinical investigations against sepsis. These promising findings hold the potential to pave the way for future clinical trials in the field.
Identifiants
pubmed: 37939908
pii: S0925-4439(23)00312-5
doi: 10.1016/j.bbadis.2023.166946
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
166946Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.