Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non-alcoholic fatty liver disease.
CaMKIIγ
ER stress
NAFLD
TXA2
hepatic insulin resistance
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
13 Sep 2023
13 Sep 2023
Historique:
revised:
18
08
2023
received:
22
05
2023
accepted:
04
09
2023
medline:
9
11
2023
pubmed:
9
11
2023
entrez:
8
11
2023
Statut:
aheadofprint
Résumé
Defective insulin signalling and dysfunction of the endoplasmic reticulum (ER), driven by excessive lipid accumulation in the liver, is a characteristic feature in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Thromboxane A TP receptor knockout (TP TXA The TXA
Sections du résumé
BACKGROUND AND PURPOSE
OBJECTIVE
Defective insulin signalling and dysfunction of the endoplasmic reticulum (ER), driven by excessive lipid accumulation in the liver, is a characteristic feature in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Thromboxane A
EXPERIMENTAL APPROACH
METHODS
TP receptor knockout (TP
KEY RESULTS
RESULTS
TXA
CONCLUSIONS AND IMPLICATIONS
CONCLUSIONS
The TXA
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Collaborative Innovationcenter of Food Safety and Quality Control in Jiangsu Province
Organisme : the Jiangsu Specially-Appointed Professor Program
Organisme : the National Youth 1000 Talents Plan
Organisme : National Natural Science Foundation of China
ID : 81773064
Organisme : National Natural Science Foundation of China
ID : 32272290
Organisme : National Natural Science Foundation of China
ID : 31972973
Organisme : Thousand Young Talents Program of China
Organisme : Jiangsu Province Recruitment Plan for High-level, Innovative and Entrepreneurial Talents (Innovative Research Team)
Informations de copyright
© 2023 British Pharmacological Society.
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