Correlation of olfactory function factors with cardiac sympathetic denervation in Parkinson's disease.
123I-meta-iodobenzylguanidine
Cardiac sympathetic denervation
Factor analysis
Olfactory function
Parkinson’s disease
Selective hyposmia
Smell identification test
Journal
Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
received:
10
08
2023
accepted:
23
10
2023
revised:
19
10
2023
medline:
27
2
2024
pubmed:
9
11
2023
entrez:
8
11
2023
Statut:
ppublish
Résumé
Hyposmia is a common nonmotor symptom of Parkinson's disease (PD) and reportedly associated with dysautonomia in PD. The smell identification test for measuring olfactory function consists of multiple items to discriminate specific scents. In the present study, factor analysis of the smell identification test was performed, and the correlation of extracted factors with cardiac sympathetic denervation (CSD) in patients with PD was investigated. The present study included 183 early PD patients who underwent the Cross-Cultural Smell Identification Test (CC-SIT) and The mean CC-SIT score was 6.1 ± 2.6, and 133 patients (72.7%) had CSD. The CC-SIT score and five smell factors were not associated with dopamine transporter uptake or cognitive functions. However, the CC-SIT score significantly correlated with age (P < 0.001) and late H/M ratio (P < 0.001). Factors 1 and 5 showed an increasing trend with larger H/M ratio, although it was not statistically significant (β = 0.203, P = 0.085 and β = 0.230, P = 0.085, respectively). Factor 5 significantly correlated with the H/M ratio in PD patients with CSD (β = 0.676, P = 0.036). The results showed olfactory dysfunction to be selectively associated with cardiac sympathetic burden in PD. The correlation of certain factors with CSD indicates the possibility of selective hyposmia in PD patients.
Sections du résumé
BACKGROUND
BACKGROUND
Hyposmia is a common nonmotor symptom of Parkinson's disease (PD) and reportedly associated with dysautonomia in PD. The smell identification test for measuring olfactory function consists of multiple items to discriminate specific scents. In the present study, factor analysis of the smell identification test was performed, and the correlation of extracted factors with cardiac sympathetic denervation (CSD) in patients with PD was investigated.
METHODS
METHODS
The present study included 183 early PD patients who underwent the Cross-Cultural Smell Identification Test (CC-SIT) and
RESULTS
RESULTS
The mean CC-SIT score was 6.1 ± 2.6, and 133 patients (72.7%) had CSD. The CC-SIT score and five smell factors were not associated with dopamine transporter uptake or cognitive functions. However, the CC-SIT score significantly correlated with age (P < 0.001) and late H/M ratio (P < 0.001). Factors 1 and 5 showed an increasing trend with larger H/M ratio, although it was not statistically significant (β = 0.203, P = 0.085 and β = 0.230, P = 0.085, respectively). Factor 5 significantly correlated with the H/M ratio in PD patients with CSD (β = 0.676, P = 0.036).
DISCUSSION
CONCLUSIONS
The results showed olfactory dysfunction to be selectively associated with cardiac sympathetic burden in PD. The correlation of certain factors with CSD indicates the possibility of selective hyposmia in PD patients.
Identifiants
pubmed: 37940708
doi: 10.1007/s00415-023-12080-8
pii: 10.1007/s00415-023-12080-8
doi:
Substances chimiques
3-Iodobenzylguanidine
35MRW7B4AD
Iodine-123
8YWR746RPQ
Iodine Radioisotopes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1397-1407Subventions
Organisme : National Research Foundation of Korea
ID : NRF-2017R1D1A1B06028086
Organisme : National Institute of Health (KR)
ID : 2021-ER1008-02
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
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