A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia.
Cerebral vascular disease
Dementia
Small vessel disease
Vascular cognitive impairment
Vascular dementia
Journal
Cerebral circulation - cognition and behavior
ISSN: 2666-2450
Titre abrégé: Cereb Circ Cogn Behav
Pays: Netherlands
ID NLM: 101774849
Informations de publication
Date de publication:
2023
2023
Historique:
received:
03
08
2023
revised:
27
09
2023
accepted:
05
10
2023
medline:
9
11
2023
pubmed:
9
11
2023
entrez:
9
11
2023
Statut:
epublish
Résumé
Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which encompasses vascular dementia (VaD) is the second most common type of dementia. Models of VCI have been delayed by limited understanding of the underlying aetiology and pathogenesis. This review by a multidisciplinary, diverse (in terms of sex, geography and career stage), cross-institute team provides a perspective on limitations to current VCI models and recommendations for improving translation and reproducibility. We discuss reproducibility, clinical features of VCI and corresponding assessments in models, human pathology, bioinformatics approaches, and data sharing. We offer recommendations for future research, particularly focusing on small vessel disease as a main underpinning disorder.
Identifiants
pubmed: 37941765
doi: 10.1016/j.cccb.2023.100189
pii: S2666-2450(23)00033-8
pmc: PMC10628644
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100189Subventions
Organisme : Chief Scientist Office
ID : CZB/4/517
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/X003418/1
Pays : United Kingdom
Informations de copyright
© 2023 The Authors. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
No conflict of Interest.
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