Lactoferrin and Activated Protein C: Potential Role in Prevention of Cancer Progression and Recurrence.
Cancer
Lactoferrin
activated protein C
cancer treatment
neutrophil extracellular traps
Journal
International journal of molecular and cellular medicine
ISSN: 2251-9637
Titre abrégé: Int J Mol Cell Med
Pays: Iran
ID NLM: 101598104
Informations de publication
Date de publication:
2023
2023
Historique:
received:
21
08
2023
revised:
10
10
2023
accepted:
17
10
2023
medline:
9
11
2023
pubmed:
9
11
2023
entrez:
9
11
2023
Statut:
ppublish
Résumé
Existing therapeutic interventions for controlling cancer are limited and associated with side effects. Furthermore, the recurrence of cancer poses a significant challenge to the cure of cancer. Therefore, avenues are wanted to find novel therapies for cancer treatment and cancer recurrence. In this review, we have highlighted that lactoferrin (LF) and activated protein C (APC) carry enormous potential in cancer treatment. Studies have shown that the decreased level of APC and impaired function of APC are associated with cancer progression and cancer-related mortality. Moreover, APC plays an important role in preventing prothrombotic state-mediated cancer progression and deaths. LF can also inhibit the progression of cancer by controlling the generation of reactive oxygen species, triggering the apoptosis of cancer cells, arresting the cell cycle and hindering the angiogenesis process. Additionally, APC and LF could have the potential to inhibit neutrophil extracellular traps (NETs) formations which are involved in cancer progression and the reawakening of dormant cancer cells. Hence, in this review, the anticancer potential and mechanism of APC and LF along with their potential to mitigate inflammation and NETs-mediated cancer progression and recurrence has been discussed. Additionally, possible future strategies to develop effective and safe anticancer treatment using LF and APC have also been discussed in this review.
Identifiants
pubmed: 37942258
doi: 10.22088/IJMCM.BUMS.12.1.86
pmc: PMC10629726
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
86-99Informations de copyright
© The Author(s).
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