Amino-Functionalized Zirconium-Based Metal-Organic Frameworks as Bifunctional Nanomaterials to Treat Bone Tumors and Promote Osteogenesis.
UiO-66-NH2
bifunctional nanomaterials
bone repair
bone tumor therapy
metal−organic framework
osteogenic differentiation
Journal
ACS applied materials & interfaces
ISSN: 1944-8252
Titre abrégé: ACS Appl Mater Interfaces
Pays: United States
ID NLM: 101504991
Informations de publication
Date de publication:
22 Nov 2023
22 Nov 2023
Historique:
medline:
23
11
2023
pubmed:
9
11
2023
entrez:
9
11
2023
Statut:
ppublish
Résumé
Bone tumor patients often encounter challenges associated with cancer cell residues and bone defects postoperation. To address this, there is an urgent need to develop a material that can enable tumor treatment and promote bone repair. Metal-organic frameworks (MOFs) have attracted the interest of many researchers due to their special porous structure, which has great potential in regenerative medicine and drug delivery. However, few studies explore MOFs with dual antitumor and bone regeneration properties. In this study, we investigated amino-functionalized zirconium-based MOF nanoparticles (UiO-66-NH
Identifiants
pubmed: 37943099
doi: 10.1021/acsami.3c11787
doi:
Substances chimiques
UiO-66
0
Metal-Organic Frameworks
0
Zirconium
C6V6S92N3C
Phosphatidylinositol 3-Kinases
EC 2.7.1.-
Organometallic Compounds
0
Doxorubicin
80168379AG
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM