Systemic Complications of Primary Biliary Cholangitis.

Humans Liver Cirrhosis, Biliary / complications Cholangitis / complications Liver Diseases / complications Osteoporosis / etiology
Bone Cholangiocarcinoma Dry eyes Hepatocellular carcinoma Lipoprotein x PBC PSC Renal

Journal

Clinics in liver disease
ISSN: 1557-8224
Titre abrégé: Clin Liver Dis
Pays: United States
ID NLM: 9710002

Informations de publication

Date de publication:
02 2024
Historique:
medline: 13 11 2023
pubmed: 10 11 2023
entrez: 9 11 2023
Statut: ppublish

Résumé

Chronic cholestasis is the hallmark clinical feature of primary biliary cholangitis. In addition to progressive liver damage, chronic cholestasis can lead to serious complications, many of which occur outside the liver. Bile acids are ligands for nuclear hormone receptors, and alterations in their concentration disrupt normal functioning of numerous different cell types. This article discusses the clinical presentation, pathophysiology, and management of pruritus (itching), fatigue, osteoporosis, hyperlipidemia, fat-soluble vitamin deficiencies, malignancies, cardiac dysfunction, bacterial cholangitis, cholemic (bile cast) nephropathy, and Sicca syndrome.

Identifiants

DOI: 10.1016/j.cld.2023.07.004 PMID: 37945153
pubmed: 37945153
pii: S1089-3261(23)00084-3
doi: 10.1016/j.cld.2023.07.004
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

115-128

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Auteurs

Mariana Zapata (M)

University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8887, USA.

Hendrick Pagan-Torres (H)

University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8887, USA.

Marlyn J Mayo (MJ)

University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8887, USA. Electronic address: Marlyn.mayo@utsouthwestern.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Systemic Complications of Primary Biliary Cholangitis.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Cirrhose du foie › Cirrhose biliaire › Systemic Complications of Primary Biliary Cholangitis.
questionsmedicales.fr › Maladies de l'appareil digestif › Maladie des voies biliaires › Maladies des canaux biliaires › Angiocholite › Systemic Complications of Primary Biliary Cholangitis.
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Systemic Complications of Primary Biliary Cholangitis.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Maladies osseuses métaboliques › Ostéoporose › Systemic Complications of Primary Biliary Cholangitis.