Mitochondrial AAA+ proteases.


Journal

The Enzymes
ISSN: 0423-2607
Titre abrégé: Enzymes
Pays: United States
ID NLM: 101637215

Informations de publication

Date de publication:
2023
Historique:
medline: 13 11 2023
pubmed: 10 11 2023
entrez: 9 11 2023
Statut: ppublish

Résumé

Mitochondria are multifunctional organelles that play a central role in a wide range of life-sustaining tasks in eukaryotic cells, including adenosine triphosphate (ATP) production, calcium storage and coenzyme generation pathways such as iron-sulfur cluster biosynthesis. The wide range of mitochondrial functions is carried out by a diverse array of proteins comprising approximately 1500 proteins or polypeptides. Degradation of these proteins is mainly performed by four AAA+ proteases localized in mitochondria. These AAA+ proteases play a quality control role in degrading damaged or misfolded proteins and perform various other functions. This chapter describes previously identified roles for these AAA+ proteases that are localized in the mitochondria of animal cells.

Identifiants

pubmed: 37945172
pii: S1874-6047(23)00028-8
doi: 10.1016/bs.enz.2023.09.002
pii:
doi:

Substances chimiques

ATPases Associated with Diverse Cellular Activities EC 3.6.4.-
Mitochondrial Proteins 0
Peptides 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

205-220

Informations de copyright

Copyright © 2023. Published by Elsevier Inc.

Auteurs

Yuichi Matsushima (Y)

Department of Biological Sciences, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan. Electronic address: ymatsushima@cm.bio.sci.osaka-u.ac.jp.

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Classifications MeSH