Mitochondrial AAA+ proteases.
AAA+ protease
ClpXP
Lon
Mitochondria
i-AAA
m-AAA
Journal
The Enzymes
ISSN: 0423-2607
Titre abrégé: Enzymes
Pays: United States
ID NLM: 101637215
Informations de publication
Date de publication:
2023
2023
Historique:
medline:
13
11
2023
pubmed:
10
11
2023
entrez:
9
11
2023
Statut:
ppublish
Résumé
Mitochondria are multifunctional organelles that play a central role in a wide range of life-sustaining tasks in eukaryotic cells, including adenosine triphosphate (ATP) production, calcium storage and coenzyme generation pathways such as iron-sulfur cluster biosynthesis. The wide range of mitochondrial functions is carried out by a diverse array of proteins comprising approximately 1500 proteins or polypeptides. Degradation of these proteins is mainly performed by four AAA+ proteases localized in mitochondria. These AAA+ proteases play a quality control role in degrading damaged or misfolded proteins and perform various other functions. This chapter describes previously identified roles for these AAA+ proteases that are localized in the mitochondria of animal cells.
Identifiants
pubmed: 37945172
pii: S1874-6047(23)00028-8
doi: 10.1016/bs.enz.2023.09.002
pii:
doi:
Substances chimiques
ATPases Associated with Diverse Cellular Activities
EC 3.6.4.-
Mitochondrial Proteins
0
Peptides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
205-220Informations de copyright
Copyright © 2023. Published by Elsevier Inc.