Transcriptional and epigenetic regulators of human CD8
Journal
Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
18
07
2023
accepted:
26
09
2023
pubmed:
10
11
2023
medline:
10
11
2023
entrez:
9
11
2023
Statut:
ppublish
Résumé
Clinical response to adoptive T cell therapies is associated with the transcriptional and epigenetic state of the cell product. Thus, discovery of regulators of T cell gene networks and their corresponding phenotypes has potential to improve T cell therapies. Here we developed pooled, epigenetic CRISPR screening approaches to systematically profile the effects of activating or repressing 120 transcriptional and epigenetic regulators on human CD8
Identifiants
pubmed: 37945901
doi: 10.1038/s41588-023-01554-0
pii: 10.1038/s41588-023-01554-0
pmc: PMC10703699
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2211-2223Subventions
Organisme : NHGRI NIH HHS
ID : UM1 HG012053
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI146356
Pays : United States
Organisme : NHGRI NIH HHS
ID : RM1 HG011123
Pays : United States
Organisme : NHGRI NIH HHS
ID : UM1 HG009428
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2023. The Author(s).
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