Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.

Journal

Nature genetics

ISSN: 1546-1718

Titre abrégé: Nat Genet

Pays: United States

ID NLM: 9216904

Informations de publication

Date de publication:
Dec 2023

Historique:

received: 21 08 2022

accepted: 15 09 2023

pubmed: 10 11 2023

medline: 10 11 2023

entrez: 9 11 2023

Statut: ppublish

Résumé

The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.

Identifiants

DOI: 10.1038/s41588-023-01534-4 PMID: 37945903

pubmed: 37945903

doi: 10.1038/s41588-023-01534-4

pii: 10.1038/s41588-023-01534-4

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

2065-2074

Subventions

Organisme : NCI NIH HHS

ID : U01 CA257328

Pays : United States

Organisme : NCI NIH HHS

ID : U01 CA261339

Pays : United States

Investigateurs

Yuji Yamanashi (Y)

Yoichi Furukawa (Y)

Takayuki Morisaki (T)

Yoshinori Murakami (Y)

Kaori Muto (K)

Akiko Nagai (A)

Wataru Obara (W)

Ken Yamaji (K)

Kazuhisa Takahashi (K)

Satoshi Asai (S)

Yasuo Takahashi (Y)

Takao Suzuki (T)

Nobuaki Sinozaki (N)

Hiroki Yamaguchi (H)

Shiro Minami (S)

Shigeo Murayama (S)

Kozo Yoshimori (K)

Satoshi Nagayama (S)

Daisuke Obata (D)

Masahiko Higashiyama (M)

Akihide Masumoto (A)

Yukihiro Koretsune (Y)

Informations de copyright

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