Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults.

Journal

Nature medicine

ISSN: 1546-170X

Titre abrégé: Nat Med

Pays: United States

ID NLM: 9502015

Informations de publication

Date de publication:
Dec 2023

Historique:

received: 20 03 2023

accepted: 29 09 2023

pubmed: 10 11 2023

medline: 10 11 2023

entrez: 9 11 2023

Statut: ppublish

Résumé

Over one million European children undergo computed tomography (CT) scans annually. Although moderate- to high-dose ionizing radiation exposure is an established risk factor for hematological malignancies, risks at CT examination dose levels remain uncertain. Here we followed up a multinational cohort (EPI-CT) of 948,174 individuals who underwent CT examinations before age 22 years in nine European countries. Radiation doses to the active bone marrow were estimated on the basis of body part scanned, patient characteristics, time period and inferred CT technical parameters. We found an association between cumulative dose and risk of all hematological malignancies, with an excess relative risk of 1.96 (95% confidence interval 1.10 to 3.12) per 100 mGy (790 cases). Similar estimates were obtained for lymphoid and myeloid malignancies. Results suggest that for every 10,000 children examined today (mean dose 8 mGy), 1-2 persons are expected to develop a hematological malignancy attributable to radiation exposure in the subsequent 12 years. Our results strengthen the body of evidence of increased cancer risk at low radiation doses and highlight the need for continued justification of pediatric CT examinations and optimization of doses.

Identifiants

DOI: 10.1038/s41591-023-02620-0 PMID: 37946058

pubmed: 37946058

doi: 10.1038/s41591-023-02620-0

pii: 10.1038/s41591-023-02620-0

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

3111-3119

Subventions

Organisme : EC | EC Seventh Framework Programm | FP7 Nuclear Fission, Safety and Radiation Protection (FP7-EURATOM-FISSION - EURATOM: Nuclear Fission and Radiation Protection)

ID : 269912

Informations de copyright

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