Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol.
GWAS
Latin American
OCD
genetic
genomic
obsessive-compulsive disorder
Journal
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISSN: 1552-485X
Titre abrégé: Am J Med Genet B Neuropsychiatr Genet
Pays: United States
ID NLM: 101235742
Informations de publication
Date de publication:
09 Nov 2023
09 Nov 2023
Historique:
revised:
26
09
2023
received:
03
04
2023
accepted:
06
10
2023
pubmed:
10
11
2023
medline:
10
11
2023
entrez:
10
11
2023
Statut:
aheadofprint
Résumé
Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.
Identifiants
pubmed: 37946624
doi: 10.1002/ajmg.b.32962
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e32962Subventions
Organisme : NIMH NIH HHS
ID : K01 MH121659
Pays : United States
Organisme : NCCIH NIH HHS
ID : 1R34AT010661-0
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH121659
Pays : United States
Organisme : NCCIH NIH HHS
ID : 1R34AT010661-0
Pays : United States
Investigateurs
Jonathan S Abramowitz
(JS)
Victor R Adorno
(VR)
Cinthia Aguirre
(C)
Gilberto S Alves
(GS)
Gustavo S Alves
(GS)
NaEshia Ancalade
(N)
Jacey L Anderberg
(JL)
Alejandro A Arellano Espinosa
(AA)
Paul D Arnold
(PD)
Elizabeth G Atkinson
(EG)
Daphne M Ayton
(DM)
Izabela G Barbosa
(IG)
Laura Marcela Barón Castano
(LMB)
Cynthia N Barrera
(CN)
María Celeste Berardo
(MC)
Dayan Berrones
(D)
John R Best
(JR)
Tim B Bigdeli
(TB)
Tania Borda
(T)
Christie L Burton
(CL)
Joseph D Buxbaum
(JD)
Jennifer L Callahan
(JL)
Carolina Cappi
(C)
Maria Cecília B Carneiro
(MCB)
Sandra L Cepeda
(SL)
Evelyn Chazelle
(E)
Jessica M Chire
(JM)
Macarena Churruca Munoz
(MC)
Pamela Claisse Quiroz
(PC)
Journa Cobite
(J)
Jonathan S Comer
(JS)
Daniel L Costa
(DL)
Jennifer Crosbie
(J)
James J Crowley
(JJ)
Victor O Cruz
(VO)
Guillermo Dager
(G)
Luisa F Daza
(LF)
Anabel de la Rosa-Gómez
(A)
Daniela Del Río
(D)
Fernanda Z Delage
(FZ)
Carolina B Dreher
(CB)
Lucila Fay
(L)
Tomas Fazio
(T)
Ygor A Ferrão
(YA)
Gabriela M Ferreira
(GM)
Edith G Figueroa
(EG)
Leonardo F Fontenelle
(LF)
Diego A Forero
(DA)
Daniele Th Fragoso
(DT)
Renee M Frederick
(RM)
Bharathi S Gadad
(BS)
Sheldon R Garrison
(SR)
Paola Giusti-Rodriguez
(P)
Laura D Gonzalez
(LD)
Andres González
(A)
Marco A González
(MA)
Polaris Gonzalez-Barrios
(P)
Wayne Goodman
(W)
Dorothy E Grice
(DE)
Jerry Guintivano
(J)
Daniel G Guttfreund
(DG)
Andrew G Guzick
(AG)
Matthew W Halvorsen
(MW)
Joseph D Hovey
(JD)
Hailiang Huang
(H)
Jonathan Irreño-Sotomonte
(J)
Reinhard Janssen-Aguilar
(R)
Matias Jensen
(M)
Alexandra Z Jimenez Reynolds
(AZ)
Joali Alexandra Juárez Lujambio
(JAJ)
Nasim Khalfe
(N)
Madison A Knutsen
(MA)
Minjee Kook
(M)
Caleb Lack
(C)
Nuria Lanzagorta
(N)
Gabriel Lázaro-Muñoz
(G)
Monicke O Lima
(MO)
Melanie O Longhurst
(MO)
David A Lozada Martinez
(DA)
Elba S Luna
(ES)
Andrea H Marques
(AH)
Molly Martinez
(M)
Mayra C Martinez Mallen
(MC)
Karen G Martinez-Gonzalez
(KG)
Maria de Los Angeles Matos
(M)
Manuel Mattheisen
(M)
Caitlyn E Maye
(CE)
Joseph F McGuire
(JF)
Gabriela Menezes
(G)
Euripedes C Miguel
(EC)
Charlene Minaya
(C)
Tomás Miño
(T)
Sara M Mithani
(SM)
Circe Montes de Oca
(CM)
Alonso Morales-Rivero
(A)
Maria E Moreira-de-Oliveira
(ME)
Olivia J Morris
(OJ)
Pablo R Moya
(PR)
María Beatriz Moyano
(MB)
Sandra I Muñoz
(SI)
Zainab Naqqash
(Z)
Humberto Nicolini
(H)
Ambar A Núñez Bracho
(AA)
Belinda E Núñez Bracho
(BE)
Maria Corina Ochoa Rojas
(MCO)
Marcos E Ochoa-Panaifo
(ME)
Luis A Olavarria Castaman
(LA)
Trinidad Olivos Balmaceda
(TO)
Iliana Ortega
(I)
Darpan I Patel
(DI)
Michele T Pato
(MT)
Ainsley K Patrick
(AK)
Mariel Paz Y Mino
(MPY)
Jose L Perales Orellana
(JL)
Bárbara Perdigão Stumpf
(BP)
Tamara Peregrina
(T)
Stacey Pereira
(S)
Tania Pérez Duarte
(TP)
Kelly L Piacsek
(KL)
Maritza Placencia
(M)
María Belén Prieto
(MB)
Lucas C Quarantini
(LC)
Yana Quarantini-Alvim
(Y)
Iaroslava C Ramos
(IC)
Renato T Ramos
(RT)
Vanessa R Ramos
(VR)
Kesley A Ramsey
(KA)
Diana Rancourt
(D)
Elise V Ray
(EV)
Margaret A Richter
(MA)
Bradley C Riemann
(BC)
Juan C Rivas
(JC)
Carolyn I Rodriguez
(CI)
Maria C Rosario
(MC)
Camilo J Ruggero
(CJ)
Angel A Ruiz-Chow
(AA)
Alejandra Ruiz-Velasco
(A)
Melisa N Sagarnaga
(MN)
Aline S Sampaio
(AS)
Leonardo C Saraiva
(LC)
Russell J Schachar
(RJ)
Sophie C Schneider
(SC)
Ethan J Schweissing
(EJ)
Laura D Seligman
(LD)
Roseli G Shavitt
(RG)
Keaton J Soileau
(KJ)
S Evelyn Stewart
(SE)
Eric A Storch
(EA)
Shaina B Storch
(SB)
Emily R Strouphauer
(ER)
Vissente Tapia Cuevas
(VT)
Kiara R Timpano
(KR)
Beatriz Treviño-de la Garza
(BT)
Alexie Vallejo-Silva
(A)
Javier Vargas-Medrano
(J)
María I Vásquez
(MI)
Guadalupe Vidal Martinez
(GV)
Saira A Weinzimmer
(SA)
Andrew D Wiese
(AD)
Mauricio A Yanez
(MA)
Gwyneth Zai
(G)
Lina M Zapata-Restrepo
(LM)
Luz M Zappa
(LM)
Raquel M Zepeda-Burgos
(RM)
Anthony W Zoghbi
(AW)
Aline Santos Sampaio
(AS)
Ana Gabriela Hounie
(AG)
Ana Paula Ribeiro
(AP)
Angela Rodrigues Souza E Silva
(AR)
Ariane Fadel Martinho
(AF)
Bárbara Luciane Perdigão Stumpf
(BLP)
Bianca Torres Mendonça de Melo Fadel
(BTM)
Camila Vale Porto
(CV)
Carina Freitas Chacur
(CF)
Carla Pereira Loureiro
(CP)
Carolina Blaya Dreher
(CB)
Carolina Cappi
(C)
Cristiane Flôres Bortoncello
(CF)
Daniel Lucas da Conceição Costa
(DL)
Daniele Tamae Hashimoto Fragoso
(DTH)
Euripedes Constantino Miguel
(EC)
Fernanda Zetola Delage
(FZ)
Flávia Cervone
(F)
Gabriela Bezerra de Menezes
(GB)
Gabriela Cirqueira de Souza Barros
(GC)
Gabriela Mourão Ferreira
(GM)
Gilberto Sousa Alves
(GS)
Gustavo Santiago Alves
(GS)
Hugo Caminha
(H)
Izabela Guimarães Barbosa
(IG)
Jaqueline Cenci
(J)
Julia Fernandes Eigenheer Muhlbauer
(JFE)
Juliana Rigue da Silva
(JR)
Leonardo Cardoso Saraiva
(LC)
Leonardo Franklin da Costa Fontenelle
(LF)
Lígia S Camba Lopez
(LS)
Livi Ferreira Testoni de Faro
(LFT)
Luan Pinheiro Domingues Moreira
(LPD)
Luana Dumans Laurito
(LD)
Lucas de Castro Quarantini
(L)
Luciana Midori Samezima
(LM)
Luiz Felipe Guimarães Dos Santos Martins
(LFG)
Marcos Vinícius Sousa de Oliveira
(MVS)
Maria Alice de Mathis
(MA)
Maria Carolina Paraíso Lopes
(MCP)
Maria Cecília Carneiro
(MC)
Maria Conceição do Rosário
(MC)
Maria Eduarda Ismerio Moreira de Oliveira
(MEIM)
Marina Martorelli Pinho
(MM)
Monicke de Oliveira Lima
(M)
Nádia Nagano
(N)
Patrycia Chedid Danna
(PC)
Pedro Pereira Fortes da Silva
(PPF)
Raquel Fernandes de Jesus Cardoso
(RF)
Renan Barbosa de Christo
(RB)
Richard Chuquel Silveira de Avila
(RCS)
Rodrigo Bolsson Radins
(RB)
Roseli Gedanke Shavitt
(RG)
Samara Dos Santos Ribeiro
(S)
Tatiane Veríssimo da Silveira Meirelles
(TV)
Thays Mendes Aguiar
(TM)
Theresa Kerolayne da Silva Sousa
(TK)
Thiago Blanco Vieira
(TB)
Vanessa Rogério Ramos
(VR)
Veronica Huhne de Vasconcellos
(VH)
Yana Quarantini Alvim
(YQ)
Ygor Arzeno Ferrão
(YA)
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2023 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals LLC.
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