Impact of Surface Ligand on the Biocompatibility of InP/ZnS Quantum Dots with Platelets.
InP/ZnS quantum dots (QDs)
fluorescence
fluorescence lifetime imaging microscopy (FLIM)
hot-injections
platelet imaging
platelets biocompatibility
Journal
Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338
Informations de publication
Date de publication:
09 Nov 2023
09 Nov 2023
Historique:
revised:
24
10
2023
received:
09
06
2023
medline:
10
11
2023
pubmed:
10
11
2023
entrez:
10
11
2023
Statut:
aheadofprint
Résumé
InP/ZnS quantum dots (QDs) have received a large focus in recent years as a safer alternative to heavy metal-based QDs. Given their intrinsic fluorescent imaging capabilities, these QDs can be potentially relevant for in vivo platelet imaging. The InP/ZnS QDs are synthesized and their biocompatibility investigated through the use of different phase transfer agents. Analysis of platelet function indicates that platelet-QD interaction can occur at all concentrations and for all QD permutations tested. However, as the QD concentration increases, platelet aggregation is induced by QDs alone independent of natural platelet agonists. This study helps to define a range of concentrations and coatings (thioglycolic acid and penicillamine) that are biocompatible with platelet function. With this information, the platelet-QD interaction can be identified using multiple methods. Fluorescent lifetime imaging microscopy (FLIM) and confocal studies have shown QDs localize on the surface of the platelet toward the center while showing evidence of energy transfer within the QD population. It is believed that these findings are an important stepping point for the development of fluorescent probes for platelet imaging.
Identifiants
pubmed: 37946631
doi: 10.1002/smll.202304881
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2304881Subventions
Organisme : Medical Research Council
ID : MR/T002573/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/16/62/32220
Pays : United Kingdom
Informations de copyright
© 2023 The Authors. Small published by Wiley-VCH GmbH.
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