Identification of Small Molecules for Prevention of Lens Epithelium-Derived Cataract Using Zebrafish.
4-PBA
Erlotinib
Lysyl hydroxylase 3
cataract
plod3
posterior capsular opacification
small molecule screen
zebrafish
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
29 Oct 2023
29 Oct 2023
Historique:
received:
23
08
2023
revised:
16
10
2023
accepted:
25
10
2023
medline:
13
11
2023
pubmed:
10
11
2023
entrez:
10
11
2023
Statut:
epublish
Résumé
Cataract is the leading cause of blindness worldwide. It can be treated by surgery, whereby the damaged crystalline lens is replaced by a synthetic lens. Although cataract surgery is highly effective, a relatively common complication named posterior capsular opacification (PCO) leads to secondary loss of vision. PCO is caused by abnormal proliferation and migration of residual lens epithelial cells (LECs) that were not removed during the surgery, which results in interruption to the passage of light. Despite technical improvements to the surgery, this complication has not been eradicated. Efforts are being made to identify drugs that can be applied post-surgery, to inhibit PCO development. Towards the goal of identifying such drugs, we used zebrafish embryos homozygous for a mutation in
Identifiants
pubmed: 37947618
pii: cells12212540
doi: 10.3390/cells12212540
pmc: PMC10650733
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Israel Science Foundation
ID : 801/17
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