GRF2 Is Crucial for Cone Photoreceptor Viability and Ribbon Synapse Formation in the Mouse Retina.
CDC42
GRF2
RAC1
cell death
cone photoreceptor
degeneration
nuclear movement
retina
ribbon synapsis
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
04 Nov 2023
04 Nov 2023
Historique:
received:
10
10
2023
revised:
27
10
2023
accepted:
03
11
2023
medline:
13
11
2023
pubmed:
10
11
2023
entrez:
10
11
2023
Statut:
epublish
Résumé
Using constitutive GRF1/2 knockout mice, we showed previously that GRF2 is a key regulator of nuclear migration in retinal cone photoreceptors. To evaluate the functional relevance of that cellular process for two putative targets of the GEF activity of GRF2 (RAC1 and CDC42), here we compared the structural and functional retinal phenotypes resulting from conditional targeting of RAC1 or CDC42 in the cone photoreceptors of constitutive GRF2
Identifiants
pubmed: 37947653
pii: cells12212574
doi: 10.3390/cells12212574
pmc: PMC10650203
pii:
doi:
Substances chimiques
Guanine Nucleotide-Releasing Factor 2
0
Rasgrf2 protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Instituto de Salud Carlos III
ID : FIS PI19/00934
Organisme : Instituto de Salud Carlos III
ID : FIS-PI22/01538
Organisme : Junta de Castilla y León
ID : SA264P18-UIC 076
Organisme : Fundación Ramón Areces
ID : CIVP19A5942
Organisme : Fundación Memoria Samuel Solórzano Barruso
ID : FS/22-2019
Organisme : Fundación Memoria Samuel Solórzano Barruso
ID : FS/32-2020
Organisme : Fundación Memoria Samuel Solórzano Barruso
ID : FS/14-2021
Références
Front Cell Neurosci. 2021 Jan 18;14:553708
pubmed: 33536874
Int J Dev Biol. 2016;60(4-6):127-39
pubmed: 27160072
PLoS One. 2012;7(10):e47180
pubmed: 23071752
Bioinformatics. 2009 Jun 1;25(11):1463-5
pubmed: 19346324
Mol Cell Neurosci. 2017 Dec;85:127-147
pubmed: 28966131
FASEB J. 2020 Aug;34(8):10242-10249
pubmed: 32539195
Front Biosci. 2008 May 01;13:4258-75
pubmed: 18508509
EMBO Rep. 2012 Aug;13(8):741-9
pubmed: 22732842
J Neurochem. 2009 Jul;110(2):641-52
pubmed: 19457086
Cell Cycle. 2015;14(14):2200-5
pubmed: 26083340
Mol Vis. 2004 Dec 27;10:1011-8
pubmed: 15635292
Invest Ophthalmol Vis Sci. 2005 Apr;46(4):1516-24
pubmed: 15790924
Biochim Biophys Acta. 2011 Apr;1815(2):170-88
pubmed: 21111786
EMBO J. 2003 Jun 16;22(12):3039-49
pubmed: 12805218
J Biol Chem. 2001 Jun 15;276(24):21878-84
pubmed: 11285260
J Immunol. 2003 Jun 1;170(11):5652-7
pubmed: 12759446
J Cell Sci. 2016 Feb 15;129(4):729-42
pubmed: 26743081
Cell Rep. 2021 Aug 3;36(5):109461
pubmed: 34348137
PLoS One. 2013;8(3):e58814
pubmed: 23516560
Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4826-31
pubmed: 10220378
Acta Physiol (Oxf). 2019 Jun;226(2):e13241
pubmed: 30554473
Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16520-5
pubmed: 17050694
Biochem Soc Trans. 2011 Dec;39(6):1790-4
pubmed: 22103527
Neuron. 2009 Oct 29;64(2):173-87
pubmed: 19874786
Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3825-35
pubmed: 16186370
Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4271-E4280
pubmed: 28484004
FASEB J. 2021 May;35(5):e21520
pubmed: 33811381
J Cell Sci. 2016 May 15;129(10):1951-61
pubmed: 27182060
Curr Biol. 1998 Jul 30-Aug 13;8(16):935-8
pubmed: 9707409
Curr Biol. 2018 Oct 8;28(19):3086-3097.e4
pubmed: 30245107
J Cell Sci. 2022 Mar 15;135(6):
pubmed: 35285496
Sci Rep. 2020 May 20;10(1):8321
pubmed: 32433491
Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7119-24
pubmed: 21471458
Nat Commun. 2014 Sep 11;5:4839
pubmed: 25208761
Neurobiol Dis. 2015 Jun;78:57-67
pubmed: 25843669
Nat Cell Biol. 2011 Jun 19;13(7):819-26
pubmed: 21685891
J Comp Neurol. 1997 Nov 10;388(1):47-63
pubmed: 9364238
Br J Ophthalmol. 1981 Jan;65(1):23-8
pubmed: 7448155
Mol Cell Biol. 2002 Apr;22(8):2498-504
pubmed: 11909944
Prog Brain Res. 2002;136:67-71
pubmed: 12143404
Small GTPases. 2017 Jan 2;8(1):26-30
pubmed: 27221061
Nat Neurosci. 2004 Nov;7(11):1195-203
pubmed: 15475953
Neuroscience. 2007 Apr 25;146(1):272-85
pubmed: 17321057
Int J Mol Sci. 2022 Jan 10;23(2):
pubmed: 35054919
Exp Eye Res. 2018 May;170:108-116
pubmed: 29486162
J Biol Chem. 2000 Aug 25;275(34):26441-8
pubmed: 10840034
Hum Mol Genet. 2011 Mar 15;20(6):1061-73
pubmed: 21177258
Invest Ophthalmol Vis Sci. 2022 Mar 2;63(3):21
pubmed: 35319739
Sci Rep. 2020 Mar 27;10(1):5647
pubmed: 32221352
Adv Exp Med Biol. 2014;800:113-31
pubmed: 24243103
Nat Rev Neurosci. 2010 Dec;11(12):812-22
pubmed: 21045860
J Neurosci. 2006 Feb 8;26(6):1721-9
pubmed: 16467520
Exp Eye Res. 2007 May;84(5):850-7
pubmed: 17343852
Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4692-703
pubmed: 27607415
Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):505-518
pubmed: 29368007
Synapse. 2013 Aug;67(8):515-31
pubmed: 23592324
Mol Cell Proteomics. 2006 Dec;5(12):2211-27
pubmed: 16959763
J Neurochem. 1994 Dec;63(6):2259-65
pubmed: 7964746
Invest Ophthalmol Vis Sci. 1986 Feb;27(2):129-35
pubmed: 3080382
J Comp Neurol. 2010 Sep 1;518(17):3604-17
pubmed: 20593360