A Pyridine Dearomatization Approach for the Gram Scale Synthesis of (±)-Sparteine.


Journal

Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393

Informations de publication

Date de publication:
24 Nov 2023
Historique:
medline: 10 11 2023
pubmed: 10 11 2023
entrez: 10 11 2023
Statut: ppublish

Résumé

Both enantiomers of sparteine have suffered from pricing and supply chain variability, which has inspired efforts toward efficient chemical synthesis. Here, we build upon our reported synthesis of the matrine-type lupin alkaloids in order to synthesize (±)-sparteine. Specifically, selective quenching of the cyclization between glutaryl chloride and pyridine with methanol provides a functionalized quinolizidine core that was elaborated to (±)-sparteine in six additional steps on gram scale. This synthesis provides a scalable route to sparteine from inexpensive commodity chemicals utilizing a dearomative cyclization. In addition, this route provides concise access to (±)-lupinine.

Identifiants

pubmed: 37948657
doi: 10.1021/acs.orglett.3c03242
pmc: PMC10683365
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8230-8233

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM118191
Pays : United States

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Auteurs

Pik Hoi Lam (PH)

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.

Jeff K Kerkovius (JK)

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.

Sarah E Reisman (SE)

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.

Classifications MeSH